Evidence map›Paper›PMID 42818949›Full record

ArticleResearch square2026

Spatial Proteomics and Epigenomics Reveal Cell Morphology and Epigenetic Gene Regulation in Human Hippocampus.

Yang Xiao, Graham Su, Yuqi Tan, Nima Asaad, Yanxiang Deng, Tianyu Li, Yao Lu, Dongjoo Kim, Gorazd B Rosoklija, Archibald Enninful and 16 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Yang XiaoDepartment of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
Graham SuDepartment of Biomedical Engineering, Yale University, New Haven, CT 06510, USA.
Yuqi TanMicrobiology and Immunology Department, School of Medicine, Stanford University, Stanford, CA 95304 USA.
Nima AsaadDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Yanxiang DengDepartment of Biomedical Engineering, Yale University, New Haven, CT 06510, USA.
Tianyu LiDepartment of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
Yao LuDepartment of Biomedical Engineering, Yale University, New Haven, CT 06510, USA.
Dongjoo KimDepartment of Biomedical Engineering, Yale University, New Haven, CT 06510, USA.
Gorazd B RosoklijaDepartment of Psychiatry, Columbia University, New York, NY, 10032 USA.
Archibald EnninfulDepartment of Biomedical Engineering, Yale University, New Haven, CT 06510, USA.
Zhiliang BaiDepartment of Biomedical Engineering, Yale University, New Haven, CT 06510, USA.ORCID 0000-0002-3977-3057
Yang LiuDepartment of Biomedical Engineering, Yale University, New Haven, CT 06510, USA.
Cheick SissokoDepartment of Psychiatry, Columbia University, New York, NY, 10032 USA.ORCID 0000-0001-8373-3450
Madeline MarianiDepartment of Psychiatry, Columbia University, New York, NY, 10032 USA.
Tingting WuHerbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA.
Phi NguyenDepartment of Psychiatry, Columbia University, New York, NY, 10032 USA.ORCID 0000-0001-5598-9213
Huiyi LiangDepartment of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
Adrienne SantiagoDepartment of Psychiatry, Columbia University, New York, NY, 10032 USA.
Andrew J DworkDepartment of Psychiatry, Columbia University, New York, NY, 10032 USA.
René HenDepartment of Psychiatry, Columbia University, New York, NY, 10032 USA.
Garry P NolanMicrobiology and Immunology Department, School of Medicine, Stanford University, Stanford, CA 95304 USA.ORCID 0000-0002-8862-9043
J John MannDepartment of Psychiatry, Columbia University, New York, NY, 10032 USA.ORCID 0000-0002-0265-6586
Sai MaDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-9785-7929
Kam W LeongDepartment of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
Maura B DupontDepartment of Psychiatry, Columbia University, New York, NY, 10032 USA.ORCID 0000-0003-3574-7641
Rong FanDepartment of Biomedical Engineering, Yale University, New Haven, CT 06510, USA.ORCID 0000-0001-7805-8059

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3M
Suicidal Behavior: Aggression Subtypes, Childhood Adversity and Stress ResponseP50MH090964 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI MANN, JOSEPH JOHN · 2013 to 2022
$23.6M
Integrated Microphysiological System of Cerebral Organoid and Blood Vessel for Disease Modeling and Neuropsychiatric Drug screeningUH3TR002151 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LEONG, KAM W · 2020 to 2022
$3.6M
Highly scalable and sensitive spatial transcriptomic and epigenomic sequencing of brain tissues from human and non-human primateRF1MH128876 · NIMH · YALE UNIVERSITY · PI FAN, RONG, SESTAN, NENAD · 2021 to 2021
$2.9M
High-performance compute cluster for biomedical computingS10OD012351 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CALIFANO, ANDREA · 2012 to 2012
$2.0M
Machine learning methods for interpreting spatial multi-omics dataR01HG012875 · NHGRI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Elham Azizi · 2023 to 2026
$1.7M
Hippocampal circuit plasticity in human normal aging and Alzheimer's DiseaseR56AG063372 · NIA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI BOLDRINI, MAURA · 2020 to 2020
$760k
Storage System for High Performance ComputingS10OD021764 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CALIFANO, ANDREA · 2016 to 2016
$600k
How the Novel Coronavirus Attacks the BrainR21AI164769 · NIAID · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI BOLDRINI, MAURA · 2021 to 2022
$442k
NCATS NIH HHS UH3 TR002151NCI NIH HHS P30 CA013696NHGRI NIH HHS R01 HG012875NIAID NIH HHS R21 AI164769NIA NIH HHS R56 AG063372NIH HHS S10 OD012351NIH HHS S10 OD021764NIMH NIH HHS P50 MH090964NIMH NIH HHS RF1 MH128876
6 · The paper itself

Abstract

We present the first spatial tri-omic (proteomic, transcriptomic, and epigenomic) taxonomy of human hippocampus, addressing two key challenges in single-cell and spatial transcriptomics: visualizing cell morphology and epigenetic gene regulation

Indexed as

human hippocampusspatial epigenomicsspatial omicsspatial proteomicsspatial transcriptomics

Identifiers

PMID42818949
PMCPMC13622823

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.