ArticleResearch square2026
Cross-Platform Analysis of Endothelial Transcriptomic Changes Associated with Diabetes.
Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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Authors and funding
6 authors.
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Abstract
Endothelial dysfunction is an early hallmark of diabetes and a key driver of diabetic vascular complications. However, the transcriptional responses of endothelial cells (ECs) to diabetic stress across different vascular beds and the extent to which cultured ECs recapitulate these changes remain incompletely understood. Here, we profiled transcriptomes of mesenteric arterial intima from non-diabetic, pre-diabetic, and type 2 diabetic donors and compared diabetes-associated differentially expressed genes with those identified in five cultured human EC subtypes, including umbilical vein, aortic, dermal microvascular, lymphatic microvascular, and liver sinusoidal ECs, exposed to high glucose and TNF-a. Human arterial intima and cultured ECs shared multiple diabetes-associated stress-response and vascular remodeling programs, with metabolic alterations more prominent in human donor ECs and inflammatory and immune pathways more pronounced in cultured ECs. Despite these context-dependent differences, we identified a subset of genes, including
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