Evidence map›Paper›PMID 42818891›Full record

ArticleResearch square2026

Species-Agnostic Tools for HPAI H5N1 Antibody and Antigen Detection in Dairy Cows, Chickens, and Humans.

Laura R H Ahlers, Nicholas Sammons, Brian S Lane, Yeming Wang, Leonid Dzantiev, Anu Mathew, Jason Abraham, Ismaila Shittu, Lyudmyla V Marushchak, Gregory C Gray and 5 more

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Laura R H AhlersMeso Scale Diagnostics, LLC.
Nicholas SammonsMeso Scale Diagnostics, LLC.
Brian S LaneMeso Scale Diagnostics, LLC.
Yeming WangMeso Scale Diagnostics, LLC.
Leonid DzantievMeso Scale Diagnostics, LLC.
Anu MathewMeso Scale Diagnostics, LLC.
Jason AbrahamMeso Scale Diagnostics, LLC.
Ismaila ShittuUniversity of Texas Medical Branch.
Lyudmyla V MarushchakUniversity of Texas Medical Branch.
Gregory C GrayUniversity of Texas Medical Branch.
Walter N HarringtonSt. Jude Children's Research Hospital.
Lisa KercherSt. Jude Children's Research Hospital.
Ahmed KandeilSt. Jude Children's Research Hospital.
Jacob N WohlstadterMeso Scale Diagnostics, LLC.
George B SigalMeso Scale Diagnostics, LLC.

Funding

A Flexible High-Throughput Immunological Assay to Support Next-Generation Influenza Vaccine StudiesUH2AI176136 · NIAID · MESO SCALE DIAGNOSTICS, LLC · PI SIGAL, GEORGE B · 2023 to 2024
$1.7M
NIAID NIH HHS UH2 AI176136
6 · The paper itself

Abstract

High Pathogenicity Avian Influenza (HPAI) A (H5N1) circulates in wild birds, causing outbreaks in domestic poultry, but recently became enzootic in the United States spilling over into various mammals, including cattle. The zoonotic potential of H5N1 clade 2.3.4.4b emphasizes the need for tools for surveillance in mammalian and avian species. We developed two species-agnostic assays using the MESO SCALE DISCOVERY

Indexed as

bridging serologyHPAIhuman healthinfluenza H5N1multiplexnucleoprotein antigen

Identifiers

PMID42818891
PMCPMC13622796

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.