ArticlemedRxiv : the preprint server for health sciences2026
Effects of sex, treatment resistance, and antidepressant treatment on monoamine oxidase B total distribution volume.
Emily Jy Kuik, Catalina Baena-Tan, Sho Moriguchi, Joeffre Braga, Laura Miler, Pablo Rusjan, Michael Bagby, M Ishrat Husain, Neil Vasdev, Toshifumi Tomoda and 3 more
Abstract readPreprint
In one paragraphArticle in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
13 authors.
Emily Jy KuikBrain Health Imaging Centre and Azrieli Centre for Neuro-Radiochemistry, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Catalina Baena-TanBrain Health Imaging Centre and Azrieli Centre for Neuro-Radiochemistry, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Sho MoriguchiDepartment of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.ORCID 0000-0001-7536-9708 Joeffre BragaBrain Health Imaging Centre and Azrieli Centre for Neuro-Radiochemistry, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Laura MilerBrain Health Imaging Centre and Azrieli Centre for Neuro-Radiochemistry, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Pablo RusjanDouglas Research Centre and Department of Psychiatry, McGill University, Montreal, QC, Canada.ORCID 0000-0003-0075-2918 Michael BagbyDepartment of Psychiatry, University of Toronto, Toronto, ON, Canada.
Neil VasdevBrain Health Imaging Centre and Azrieli Centre for Neuro-Radiochemistry, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.ORCID 0000-0002-2087-5125 Toshifumi TomodaDepartment of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.ORCID 0000-0003-3587-0914 Mounira BanasrDepartment of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.
Jeffrey H MeyerBrain Health Imaging Centre and Azrieli Centre for Neuro-Radiochemistry, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.ORCID 0000-0003-4684-5052 Funding
Neuroimaging MAO-B in Medication Free and Treatment Resistant Major Depressive Disorder Using Novel MAO-B Tracer [11C]SL2511.88R01MH115014 · NIMH · CENTRE FOR ADDICTION AND MENTAL HEALTH · PI MEYER, JEFFREY H · 2018 to 2022
$1.2MNIMH NIH HHS R01 MH115014
6 · The paper itselfAbstract
Monoamine oxidase B (MAO-B) is a high-density protein located mainly in astrocytes that influences mitochondrial function and transition to astrogliosis. MAO-B produces hydrogen peroxide while metabolizing non-serotonergic monoamines. Elevated MAO-B level is implicated in the pathophysiology of several common neuropsychiatric diseases. The aims are to examine the effect of treatment resistant major depressive episodes, sex, and antidepressant treatment on MAO-B total distribution volume ([
Identifiers
PMID42818885
PMCPMC13622770
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