Evidence map›Paper›PMID 42818835›Full record

ArticlebioRxiv : the preprint server for biology2026

Transient morphogenetic constraints organize self-assembling axon neighborhoods for robust yet flexible wiring.

Christopher A Brittin, Anthony Santella, Kristopher Barnes, Mark W Moyle, Li Fan, Ryan Christensen, Irina Kolotuev, William A Mohler, Hari Shroff, Daniel A Colón-Ramos and 1 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Christopher A BrittinDevelopmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0002-1143-554X
Anthony SantellaDevelopmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Kristopher BarnesDevelopmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0003-2546-9529
Mark W MoyleDepartments of Neuroscience and Cell Biology, Yale University School of Medicine, New Haven, CT 06536, USA.ORCID 0009-0007-8609-0164
Li FanDevelopmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Ryan ChristensenJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Irina KolotuevDepartment of Biomedical Sciences, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0003-1433-8048
William A MohlerDepartment of Genetics and Genome Sciences and Center for Cell Analysis and Modeling, University of Connecticut Health Center, Farmington, CT 06030, USA.ORCID 0000-0003-3586-547X
Hari ShroffJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Daniel A Colón-RamosDepartments of Neuroscience and Cell Biology, Yale University School of Medicine, New Haven, CT 06536, USA.ORCID 0000-0003-0223-7717
Zhirong BaoDevelopmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0002-2201-2745

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
WormGUIDES: A Resource for Global Understanding in Dynamic Embryonic SystemsR24OD016474 · OD · YALE UNIVERSITY · PI BAO, ZHIRONG, COLON-RAMOS, DANIEL A · 2013 to 2020
$6.5M
Powering the Brain: the Cell Biology of NeuroenergeticsDP1NS111778 · NINDS · YALE UNIVERSITY · PI COLON-RAMOS, DANIEL A · 2018 to 2022
$5.9M
Cellular and molecular mechanisms that temporally and spatially restrict synapticR01NS076558 · NINDS · YALE UNIVERSITY · PI COLON-RAMOS, DANIEL A · 2012 to 2022
$4.1M
In vivio single-cell analysis of dynamic cell behaviorsR01GM152927 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI ANNA-KATERINA HADJANTONAKIS · 2024 to 2026
$1.4M
Molecular and cellular mechanisms required for fascicle organization during neurodevelopmentF32NS098616 · NINDS · YALE UNIVERSITY · PI MOYLE, MARK WAYNE · 2016 to 2018
$192k
NCI NIH HHS P30 CA008748NIGMS NIH HHS R01 GM152927NIH HHS P40 OD010440NIH HHS R24 OD016474NINDS NIH HHS DP1 NS111778NINDS NIH HHS F32 NS098616NINDS NIH HHS R01 NS076558
6 · The paper itself

Abstract

Nervous systems form wiring patterns that are reproducible across individuals. This reproducibility is thought to emerge from molecular encoding and developmental events, but their relative contributions remain unclear. We address this question in the

Identifiers

PMID42818835
PMCPMC13622697

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.