Evidence map›Paper›PMID 42818794›Full record

ArticleFrontiers in immunology2026

Targeting a malaria merozoite surface protein with mRNA vaccine generates multifunctional antibodies.

Adam Thomas, Tom Rünz, Timothy K C Ho, Stewart Fabb, Chee Leng Lee, Sandra Chishimba, Rekha Shandre Mugan, Linda Reiling, Liriye Kurtovic, Claretta S D'Souza and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Adam ThomasLife Sciences, Burnet Institute, Melbourne, VIC, Australia.
Tom Rünz *Life Sciences, Burnet Institute, Melbourne, VIC, Australia.
Timothy K C Ho *Life Sciences, Burnet Institute, Melbourne, VIC, Australia.
Stewart FabbMonash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia.
Chee Leng LeeMonash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia.
Sandra ChishimbaLife Sciences, Burnet Institute, Melbourne, VIC, Australia.
Rekha Shandre MuganMonash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia.
Linda ReilingLife Sciences, Burnet Institute, Melbourne, VIC, Australia.
Liriye KurtovicLife Sciences, Burnet Institute, Melbourne, VIC, Australia.
Claretta S D'SouzaLife Sciences, Burnet Institute, Melbourne, VIC, Australia.
Colin PoutonMonash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia.
James G BeesonLife Sciences, Burnet Institute, Melbourne, VIC, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Malaria is a leading health problem with high disease burden and mortality rates worldwide. Currently approved vaccines target the sporozoite form of Methods: We developed and evaluated monovalent and bivalent (3D7 and FC27 variants) Results: mRNA vaccines induced prominent IgG responses using monovalent (3D7 allele) and bivalent (3D7 and FC27 alleles) vaccines encoding near full-length Conclusions:

Indexed as

Antibodies, ProtozoanAntigens, ProtozoanMalaria, FalciparumMalaria VaccinesMerozoitesmRNA VaccinesPlasmodium falciparumProtozoan ProteinsAnimalsFemaleHumansImmunoglobulin GMiceMice, Inbred BALB CVaccines, SyntheticAntibodies, ProtozoanAntigens, ProtozoanImmunoglobulin GMalaria Vaccinesmerozoite surface protein 2, PlasmodiummRNA VaccinesProtozoan ProteinsVaccines, SyntheticcomplementFc-receptorsfunctional antibodiesmalariamerozoite surface protein 2mRNAphagocytosisvaccine

Identifiers

PMID42818794
PMCPMC13624079

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.