Evidence map›Paper›PMID 42818787›Full record

ArticlebioRxiv : the preprint server for biology2026

ALS-associated exitron splicing produces UBQLN2 isoforms with distinct properties.

Adenine Si-Hui Koo, Jingjing Zhou, Natasha M Méndez-Albelo, Yuchun Wei, Wei Xu, Xinyu Zhao, Colin Dewey, Randal S Tibbetts

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Adenine Si-Hui KooDepartment of Radiation Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, 53705, USA.ORCID 0009-0005-0258-7540
Jingjing ZhouCellular and Molecular Biology Training Program, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.
Natasha M Méndez-AlbeloWaisman Center, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.
Yuchun WeiDepartment of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.
Wei XuMcArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.
Xinyu ZhaoWaisman Center, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.ORCID 0000-0002-5128-4424
Colin DeweyDepartment of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.ORCID 0000-0003-1498-9254
Randal S TibbettsDepartment of Radiation Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, 53705, USA.ORCID 0000-0003-2245-2297

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
Waisman Center Intellectual and Developmental Disabilities Research CenterP50HD105353 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Brittany Gail Travers · 2021 to 2026
$8.5M
Graduate Training in Molecular and Cellular PharmacologyT32GM141013 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anjon Audhya, Aaron Matthew LeBeau · 2021 to 2026
$3.2M
Protein Arginine Methylation in Breast CancerR01CA236356 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Wei Xu · 2019 to 2026
$2.9M
Interrogate FMRP functions in primate brain developmentR01MH136152 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI Xinyu Zhao · 2024 to 2026
$2.2M
Ctr9 as a Predictive Biomarker for EZH2 Inhibitor SensitivityR01CA268183 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Wei Xu · 2022 to 2026
$2.0M
FMRP regulation of mitochondria and metabolism in mammalian brain developmentR01NS138268 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI Xinyu Zhao · 2024 to 2026
$1.9M
Genetic analysis of UBQLN2-associated neurodegeneration in frontotemporal dementiaRF1AG069483 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI TIBBETTS, RANDAL SCOT · 2020 to 2020
$1.7M
Genetic analysis of UBQLN2-associated neurodegeneration in frontotemporal dementiaR01AG069483 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Randal Scot Tibbetts · 2024 to 2026
$932k
NCI NIH HHS P30 CA014520NCI NIH HHS R01 CA236356NCI NIH HHS R01 CA268183NIA NIH HHS R01 AG069483NIA NIH HHS RF1 AG069483NICHD NIH HHS P50 HD105353NIGMS NIH HHS T32 GM141013NIMH NIH HHS R01 MH136152NINDS NIH HHS R01 NS138268Wellcome Trust
6 · The paper itself

Abstract

X-linked amyotrophic lateral sclerosis (ALS) implicated Ubiquilin 2 (UBQLN2) is expressed from a single exon. Here, we show that human UBQLN2 mRNA is alternatively spliced by virtue of a cryptic exonic intron (exitron) spanning the 5' untranslated region and the 5' end of

Identifiers

PMID42818787
PMCPMC13622671

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.