ArticleFrontiers in microbiology2026
A study on oral microbiome characteristics and differences in epilepsy adults with depressive symptoms based on 16S rRNA sequencing.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Depression is a common comorbidity in epilepsy, but its underlying mechanisms are poorly understood. Although the "oral-brain axis" has gained increasing attention in neuropsychiatric disorders, oral microbial characteristics in epileptic patients with depressive symptoms remain largely unexplored. This study aimed to compare the oral microbial composition between epileptic patients with and without depressive symptoms and to identify bacterial genera and functional pathways that may be associated with depressive symptoms. Methods: The study included 59 adult patients with epilepsy. Based on the Neuropsychiatric Depression Scale for Epilepsy (NDDI-E) scores, the participants were divided into two groups: patients with epilepsy with depressive symptoms (EDS, NDDI-E > 12, Results: No significant differences were found between the two groups in terms of general clinical data or oral microbial diversity (α- and β-diversity). Using an uncorrected Conclusion: This study utilizing 16S rRNA sequencing elucidates alterations in the oral microbiome associated with epilepsy and concurrent depressive symptoms. Significantly, the enrichment of
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