Evidence map›Paper›PMID 42818706›Full record

ArticleFrontiers in nutrition2026

Inflammatory, antioxidant, and gut microbiota-related dietary indices and gastric cancer risk: a case-control study.

Yongjing Chen, Rong Yang, Qingzhen Song, Yuan Li, Junjie Ma

Abstract read
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Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Yongjing Chen *Department of Gastroenterology, Shanxi Cancer Hospital, Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi, China.
Rong Yang *Department of Gastroenterology, Shanxi Cancer Hospital, Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi, China.
Qingzhen SongDepartment of General Internal Medicine, Shanxi Cancer Hospital, Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi, China.
Yuan LiDepartment of Gastroenterology, Shanxi Cancer Hospital, Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi, China.
Junjie MaDepartment of Gastrointestinal Surgery, Shanxi Cancer Hospital, Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Dietary patterns may influence gastric carcinogenesis through inflammatory, oxidative, intestinal permeability, and gut microbiota-related pathways. However, comprehensive studies simultaneously evaluating inflammatory, antioxidant, and microbiota-oriented dietary indices together with multiple biological biomarkers in gastric cancer remain limited. Methods: This case-control study included 960 adults comprising 480 patients with histologically confirmed gastric cancer and 480 control participants. Dietary intake was assessed using a validated food frequency questionnaire. The Dietary Inflammatory Index (DII), Composite Dietary Antioxidant Index (CDAI), and Dietary Index for Gut Microbiota (DI-GM) were calculated and categorized into tertiles. Inflammatory, oxidative stress, intestinal permeability, and microbiota-related biomarkers were measured using standardized laboratory methods. Multivariable logistic regression analyses were performed to evaluate associations between dietary indices and gastric cancer risk. Results: Patients with gastric cancer had significantly higher DII scores and significantly lower CDAI and DI-GM scores compared with controls (all Conclusion: In conclusion, proinflammatory dietary patterns were associated with greater odds of gastric cancer, whereas diets rich in antioxidants or supportive of gut microbiota showed inverse associations. These associations were accompanied by differences in inflammatory, oxidative stress, intestinal permeability, and microbial metabolism related biomarkers. However, due to the case-control design, causality cannot be inferred, and the findings should be considered associational rather than causal.

Indexed as

dietary inflammatory indexgastric cancergut microbiotaintestinal permeabilityoxidative stress

Identifiers

PMID42818706
PMCPMC13623746

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