Evidence map›Paper›PMID 42818683›Full record

ArticlebioRxiv : the preprint server for biology2026

Cryo-EM structure of detergent-bound

Yirui Guo, Bradley Quade, Karolina P Stepien, Tabitha Emde, Alfa Herrera, Raquel Bromberg, Robert Jedrzejczak, Youngchang Kim, Andrzej Joachimiak, Karla J F Satchell and 3 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yirui GuoDepartment of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0001-7705-5454
Bradley QuadeDepartment of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Karolina P StepienDepartment of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0003-0373-8919
Tabitha EmdeDepartment of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Alfa HerreraDepartment of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.ORCID 0000-0002-7081-4208
Raquel BrombergDepartment of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0003-3526-6362
Robert JedrzejczakCenter for Structural Biology of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Youngchang KimCenter for Structural Biology of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.ORCID 0000-0002-1610-4889
Andrzej JoachimiakCenter for Structural Biology of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.ORCID 0000-0003-2535-6209
Karla J F SatchellDepartment of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.ORCID 0000-0003-3274-7611
Josep RizoDepartment of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0003-1773-8311
Dominika BorekDepartment of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-4321-6253
Zbyszek OtwinowskiDepartment of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0003-3640-8545

Funding

TO PROVIDE SCIENTIFIC SUPPORT TO THE CENTERS FOR RESEARCH ON STRUCTURAL BIOLOGY OF INFECTIOUS DISEASES.75N93022C00035 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SATCHELL, KARLA · 2022 to 2025
$20.7M
Mechanisms of neurotransmitter release and its regulationR35NS097333 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI RIZOREY, JOSE · 2017 to 2024
$7.0M
Vibrio MARTX toxin effectors in signaling and pathogenesisR37AI092825 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Karla J F Satchell · 2022 to 2026
$2.5M
From complex data to complex structures: new methods for structural biologyR35GM145365 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI ZBYSZEK OTWINOWSKI · 2022 to 2026
$2.3M
Reliable model building for cryo-EMR44GM137671 · NIGMS · LIGO ANALYTICS, INC. · PI BROMBERG, RAQUEL · 2022 to 2023
$1.7M
Small host GTPases: Direct targets of Vibrio vulnificus MARTX toxin effectorsK99AI167819 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HERRERA, ALFA · 2021 to 2022
$197k
NIAID NIH HHS HHSN272201200026CNIAID NIH HHS K99 AI167819NIAID NIH HHS R37 AI092825NIGMS NIH HHS R35 GM145365NIGMS NIH HHS R44 GM137671NIH HHS 75N93022C00035NINDS NIH HHS R35 NS097333
6 · The paper itself

Abstract

The tripartite toxin MakA/MakB/MakE from

Identifiers

PMID42818683
PMCPMC13622607

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.