ArticlebioRxiv : the preprint server for biology2026
Quantitative and sensitive neuroblastoma minimal residual disease detection using extrachromosomal DNA (ecDNA) breakpoints.
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In one paragraph
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
28 authors.
Annabell SzymanskyDepartment of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0003-4797-4526
Falk HertwigDepartment of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0003-4784-6516
Annika WinklerDepartment of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0009-0007-9434-3862
Rocío Chamorro GonzálezDepartment of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0002-5653-7259
Konstantin HelmsauerDepartment of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0003-0773-4114
Anna-Marie SchroeerDepartment of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Melanie J WitthauerDepartment of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Eliz KaramanDepartment of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Marco LodriniDepartment of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0003-4434-529X
Jasmin WünschelDepartment of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0009-0007-5658-7532
Nadine WittstruckDepartment of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0009-0000-4378-3226
Steffen FuchsDepartment of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0001-9619-4329
Jessica TheissenDepartment of Pediatric Hematology and Oncology, Universitätsklinikum Köln, Köln, Germany.ORCID 0000-0003-3182-1066
Barbara HeroDepartment of Pediatric Hematology and Oncology, Universitätsklinikum Köln, Köln, Germany.ORCID 0000-0003-4129-890X
Richard KocheBerlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-6820-5083
Malwine J BarzDepartment of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0003-1581-2020
Lukas C HeukampDivision of Molecular Biology, Institut für Hämatopathologie Hamburg, Hamburg, Germany.ORCID 0000-0002-3388-3482
Kathy AstrahantseffDepartment of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0002-7872-1997
Karin SchmelzDepartment of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0009-0009-6954-9927
Patrick HundsdoerferDepartment of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0009-0007-1158-5170
Joern ToedlingDepartment of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0003-1471-1295
Angelika EggertDepartment of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0003-3476-8184
Cornelia EckertDepartment of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0003-1039-2872
Bastiaan SpanjaardDepartment of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0003-1309-8839
Hedwig E DeubzerDepartment of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0002-6115-4893
Matthias FischerDepartment of Pediatric Hematology and Oncology, Universitätsklinikum Köln, Köln, Germany.ORCID 0000-0002-7865-7868
Anton G HenssenDepartment of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0003-1534-778X
Johannes H SchulteGerman Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0003-0671-1201
Funding
eDyNAmiC - CHARITEOT2CA278644 · NCI · CHARITE, UNIVERSITAETSMEDIZIN BERLIN · PI HENSSEN, ANTON GEORGE · 2022 to 2024
$214kNCI NIH HHS OT2 CA278644
Abstract
Sensitive detection of minimal residual disease (MRD) remains a major unmet need in high-risk neuroblastoma.
Indexed as
breakpointdiagnosticsecDNAextrachromosomal DNAMRDMYCNneuroblastoma
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.