Evidence map›Paper›PMID 42818605›Full record

ArticlebioRxiv : the preprint server for biology2026

Social isolation is associated with microRNA expression changes in the visual system of poison frog tadpoles.

Neil M Khosla, Max M Madrzyk, Keira Nakamura, Mei Li Gallardo Palmeri, Julie M Butler, Lauren A O'Connell

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Neil M KhoslaStanford University, Department of Biology, 371 Jane Stanford Way, Stanford, CA 94305, USA.ORCID 0000-0002-2136-8184
Max M MadrzykStanford University, Department of Biology, 371 Jane Stanford Way, Stanford, CA 94305, USA.ORCID 0009-0005-7973-6364
Keira NakamuraStanford University, Department of Biology, 371 Jane Stanford Way, Stanford, CA 94305, USA.ORCID 0009-0009-8054-6049
Mei Li Gallardo PalmeriStanford University, Department of Biology, 371 Jane Stanford Way, Stanford, CA 94305, USA.
Julie M ButlerStanford University, Department of Biology, 371 Jane Stanford Way, Stanford, CA 94305, USA.
Lauren A O'ConnellStanford University, Department of Biology, 371 Jane Stanford Way, Stanford, CA 94305, USA.ORCID 0000-0002-2706-4077

Funding

Dopamine regulation of infant perceptual motor development and communicationR01HD110514 · NICHD · STANFORD UNIVERSITY · PI Lauren A O'Connell · 2023 to 2026
$2.3M
microRNA tuning of gregarious versus antisocial behavior in juvenilesR56MH133094 · NIMH · STANFORD UNIVERSITY · PI O'CONNELL, LAUREN A · 2023 to 2023
$397k
NICHD NIH HHS R01 HD110514NIMH NIH HHS R56 MH133094
6 · The paper itself

Abstract

Brain microRNA (miRNA) expression can shift in response to the social environment, translating external cues into regulatory action that can influence brain structure, neural activity, and behavior. miRNAs are key drivers of behavioral flexibility, regulating gene networks involved in neuroplasticity. We manipulated social rearing conditions of brilliant-thighed poison frog tadpoles (

Indexed as

microRNAparathyroid hormone 2plasticitypoison frogretinotectalsocial isolation

Identifiers

PMID42818605
PMCPMC13622530

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.