Evidence map›Paper›PMID 42818585›Full record

ArticleFrontiers in immunology2026

Cuproptosis-associated genes

Jing Wang, Ya-Hui Hu, Bo Wang, Qi Liu, Yi-Dan Zhang, Kun-Mu Zheng, Nai-An Xiao, Li-Xi Li, Bin Jiang

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jing Wang *Department of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Ya-Hui Hu *Xiamen Key Laboratory of Brain Center, Xiamen, China.
Bo WangDepartment of Radiology, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Qi LiuDepartment of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Yi-Dan ZhangDepartment of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Kun-Mu ZhengDepartment of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Nai-An XiaoDepartment of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Li-Xi LiDepartment of Neurology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Bin JiangDepartment of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder whose pathogenesis involves complex interactions between metabolic dysfunction and neuroinflammation. The role of cuproptosis, a newly defined copper-dependent cell death pathway that is triggered during mitochondrial aerobic respiration, in PD remains incompletely understood. In this study, we employed integrated bioinformatics on bulk and single-cell RNA sequencing datasets to identify four hub cuproptosis-associated genes (

Indexed as

CuproptosisLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Parkinson DiseaseAnimalsAstrocytesDisease Models, AnimalGene Expression ProfilingHumansMiceMicrogliaMultiomicsProtein Serine-Threonine KinasesTranscriptomeLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Protein Serine-Threonine Kinasescuproptosismulti-omicsmultiplex immunofluorescenceParkinson‘s diseasePD mouse model

Identifiers

PMID42818585
PMCPMC13623572

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.