ArticleFrontiers in medicine2026
White matter hyperintensity radiomics predicts 90-day diffusion-weighted imaging-confirmed acute ischemic stroke after diffusion-weighted imaging-negative transient ischemic attack: preliminary findings from a retrospective machine-learning study.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To develop and internally validate a T2-fluid-attenuated inversion recovery (T2-FLAIR) white matter hyperintensity (WMH) radiomics model, alone and in combination with baseline clinical variables, for predicting diffusion-weighted imaging (DWI)-confirmed acute ischemic stroke (AIS) within 90 days after an index DWI-negative transient ischemic attack (TIA). Methods: This single-center retrospective study included 398 patients initially diagnosed with DWI-negative TIA between January 2021 and May 2025 who underwent repeat brain magnetic resonance imaging with DWI within 90 days because of recurrent transient neurological symptoms and were classified into AIS ( Results: In the training cohort, the combined model achieved the highest area under the curve (AUC) (0.900, 95% CI: 0.860-0.940), followed by the radiomics model (0.862, 95% CI: 0.812-0.912) and the clinical model (0.775, 95% CI: 0.720-0.830). In the testing cohort, the radiomics model achieved the highest AUC (0.854, 95% CI: 0.757-0.950), followed by the combined model (0.841, 95% CI: 0.748-0.935) and the clinical model (0.696, 95% CI: 0.568-0.824). Conclusion: These preliminary findings indicate that T2-FLAIR WMH radiomics may provide promising internal discrimination for predicting 90-day DWI-confirmed AIS after DWI-negative TIA in this selected high-risk cohort. The incremental value of adding clinical variables to radiomics was not confirmed in the internal testing cohort, and prospective multicenter validation is required.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.