Evidence map›Paper›PMID 42818529›Full record

ArticleResearch square2026

Transcriptome changes of disinhibited somatostatin neurons in the medial prefrontal cortex mediating male-specific stress resilience.

Meiyu Shao, Deepro Banerjee, Anirban Paul, Santhosh Girirajan, Bernhard Lüscher

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Meiyu ShaoDepartment of Biology, The Pennsylvania State University, University Park, PA.
Deepro BanerjeeDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA.
Anirban PaulDepartment of Neuroscience and Experimental Therapeutics, Penn State College of Medicine, Hershey, PA.
Santhosh GirirajanDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA.
Bernhard LüscherDepartment of Biology, The Pennsylvania State University, University Park, PA.ORCID 0000-0003-1375-1906

Funding

GABAergic Control of Depression Related Brain StatesR01MH099851 · NIMH · PENNSYLVANIA STATE UNIVERSITY, THE · PI LUSCHER, BERNHARD · 2013 to 2019
$3.2M
NIMH NIH HHS R01 MH099851
6 · The paper itself

Abstract

Somatostatin (SST)-expressing interneurons are critical modulators of vulnerability to chronic stress and are strongly implicated in the pathophysiology of stress-related affective disorders. Consistent with this role, we have recently demonstrated that selective enhancement of SST neuron activity-achieved via cell type-specific Cre-mediated inactivation of GABA

Indexed as

Alzheimer’s diseaseantidepressant drug actionanxietydepression

Identifiers

PMID42818529
PMCPMC13622854

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.