Evidence map›Paper›PMID 42818520›Full record

ArticlebioRxiv : the preprint server for biology2026

Loss of short-form Ron promotes B and T cell cooperation to prevent outgrowth of breast cancer bone metastasis.

Clint H Valencia, Marija Nadjsombati, Truc Pham, Danny Soltero, Navina Devarajan, Jaime Fornetti, Alana L Welm

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Clint H ValenciaDepartment of Oncological Sciences, University of Utah, Salt Lake City, Utah.
Marija NadjsombatiDepartment of Oncological Sciences, University of Utah, Salt Lake City, Utah.
Truc PhamDepartment of Oncological Sciences, University of Utah, Salt Lake City, Utah.
Danny SolteroDepartment of Oncological Sciences, University of Utah, Salt Lake City, Utah.
Navina DevarajanDepartment of Oncological Sciences, University of Utah, Salt Lake City, Utah.
Jaime FornettiDepartment of Oncological Sciences, University of Utah, Salt Lake City, Utah.
Alana L WelmDepartment of Oncological Sciences, University of Utah, Salt Lake City, Utah.ORCID 0000-0002-1412-1351

Funding

UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 1986 to 2026
$72.6M
NCI NIH HHS P30 CA042014
6 · The paper itself

Abstract

While immunotherapy has great potential to eradicate tumors, success in metastatic breast cancer is limited. Bone metastasis, the most common site for breast cancer metastasis, has been associated with weakened anti-tumor immunity, both in the bone and in other metastatic sites. Additional strategies promoting anti-tumor immunity are needed. Using the MMTV-PyMT intratibial model of breast cancer bone metastasis, we discovered that deletion of host short-form Ron (Ron SF

Identifiers

PMID42818520
PMCPMC13622458

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.