Evidence map›Paper›PMID 42818511›Full record

ArticleResearch square2026

Clonal CD8 T cells link peripheral and intrathecal immunity in ALS4 progression: a multiomics reference for ALS.

Marina Terekhova, Rima Melhem, Carisa Zeng, Jessie Martin, Tanya Lizbeth Joseph, Pavla Bohacova, Melina Jones, Avindra Nath, Nicole Benoit, George Harmison and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Marina TerekhovaDepartment of Pathology and Immunology, Washington University in Saint Louis, Saint Louis, Missouri, USA.
Rima MelhemDepartment of Pathology and Immunology, Washington University in Saint Louis, Saint Louis, Missouri, USA.
Carisa ZengDepartment of Pathology and Immunology, Washington University in Saint Louis, Saint Louis, Missouri, USA.ORCID 0000-0002-7108-3873
Jessie MartinDepartment of Pathology and Immunology, Washington University in Saint Louis, Saint Louis, Missouri, USA.
Tanya Lizbeth JosephDepartment of Pathology and Immunology, Washington University in Saint Louis, Saint Louis, Missouri, USA.
Pavla BohacovaDepartment of Pathology and Immunology, Washington University in Saint Louis, Saint Louis, Missouri, USA.
Melina JonesSection of Infections of The Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
Avindra NathSection of Infections of The Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0003-0927-5855
Nicole BenoitBiospecimen Core, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
George HarmisonNeurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, US.
Gregory F WuDepartment of Pathology and Immunology, Washington University in Saint Louis, Saint Louis, Missouri, USA.ORCID 0000-0003-3588-0637
Alexey SergushichevDepartment of Pathology and Immunology, Washington University in Saint Louis, Saint Louis, Missouri, USA.
Maxim N ArtyomovDepartment of Pathology and Immunology, Washington University in Saint Louis, Saint Louis, Missouri, USA.ORCID 0000-0002-1133-4212
Christopher GrunseichNeurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, US.ORCID 0000-0003-4994-2472
Laura CampisiDepartment of Pathology and Immunology, Washington University in Saint Louis, Saint Louis, Missouri, USA.

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Studies of inherited neuromuscular diseasesZIANS009455 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI GRUNSEICH, CHRISTOPHER · 2024 to 2025
$5.6M
CAR-T cell treatment of CNS AutoimmunityR01AI165771 · NIAID · WASHINGTON UNIVERSITY · PI HSIEH, CHYI S, WU, GREGORY · 2022 to 2025
$3.4M
T cell Immunity in a Rare Juvenile Form of Motor Neuron DiseaseR01NS123287 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Laura Campisi, Ivan Marazzi · 2023 to 2026
$2.6M
CSRD VA I01 CX002383Intramural NIH HHS ZIA NS009455NCATS NIH HHS UL1 TR002345NIAID NIH HHS R01 AI165771NINDS NIH HHS R01 NS123287
6 · The paper itself

Abstract

Dysregulated immune responses increasingly appear central to amyotrophic lateral sclerosis (ALS) pathology, but rapid progression and delayed diagnosis limit our understanding of how immune events evolve over the course of disease. By combining high-parameter spectral flow cytometry with single-cell RNA, TCR and BCR sequencing of peripheral blood and cerebrospinal fluid (CSF), we map the immune landscape in ALS4, a juvenile-onset, slowly progressive ALS subtype, providing the first view of immune states spanning decades of disease progression. We identify an early-emerging, progressively amplifying CD8 T cell program characterized by clonal expansion of peripheral GZMK

Identifiers

PMID42818511
PMCPMC13622822

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.