Evidence map›Paper›PMID 42818510›Full record

ArticlebioRxiv : the preprint server for biology2026

Noninvasive Focal Gene Delivery of Functional Neural Actuators to the Primate Spinal Cord using Focused Ultrasound.

M R Corigliano, S S Guretse, N T Nosenchuck, I Zimmermann Rollin, L Letica, D Szczupak, V P Campos, L Liang, M C Noh, T K Hitchens and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

M R CoriglianoDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0002-7403-0750
S S GuretseDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
N T NosenchuckDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
I Zimmermann RollinDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213, USA.
L LeticaDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
D SzczupakDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
V P CamposDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
L LiangDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213, USA.
M C NohDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
T K HitchensDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
E PirondiniDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213, USA.
R SealDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
M K LinDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
D J SchaefferDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Funding

The Behavioral Brain (B2) Research Training ProgramT32GM142630 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Julie A Fiez, MATTHEW A SMITH · 2022 to 2026
$1.8M
A novel method for transient and repeatable axonal tracing in developing marmosetsR21NS125372 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SCHAEFFER, DAVID J · 2022 to 2022
$428k
NIGMS NIH HHS T32 GM142630NINDS NIH HHS R21 NS125372
6 · The paper itself

Abstract

Pathologies of the spinal cord - from degenerative diseases to chronic pain - represent a substantial global health burden. Although surgical and pharmacological treatments for spinal cord pathologies have advanced considerably, therapies capable of addressing the cellular mechanisms underlying these conditions remain limited. Viral gene therapies present a compelling alternative, allowing for delivery of therapeutic genes that directly target the pathological processes in specific cell-types. Effective viral delivery to the spinal cord, however, remains constrained by a fundamental tradeoff between procedural invasiveness and spatial precision. As such, there remains a need for clinically tractable methods - that are both noninvasive and focal - to deliver gene therapeutics across the restrictive vascular boundaries of the blood-spinal cord barrier (BSCB). Here, we demonstrate noninvasive, focal disruption of the BSCB and delivery of systemically administered chemogenetic gene payloads to the cervical and thoracic spinal cord in marmoset nonhuman primates (

Indexed as

Adeno-Associated VirusBlood-spinal Cord BarrierChemogeneticsCommon MarmosetFocused UltrasoundNonhuman Primate

Identifiers

PMID42818510
PMCPMC13622475

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.