Evidence map›Paper›PMID 42818433›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Novel type 1 diabetes polygenic scores improve identification of type 1 diabetes in diverse populations.

Stella Nam, Raymond J Kreienkamp, Jiang Li, Ravi Mandla, Huy Tran, Katherine Taylor, Maheak Vora, Alicia Huerta-Chagoya, Jun Wei, Ashley J Mulford and 11 more

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Stella NamDiabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-9049-2680
Raymond J KreienkampDiabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-1683-323X
Jiang LiDepartment of Genomic Health, Geisinger, Danville, PA, USA.ORCID 0000-0002-7006-1285
Ravi MandlaGraduate Program in Genomics and Computational Biology, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-0782-0138
Huy TranEndeavor Health, Evanston, IL, USA.
Katherine TaylorPrograms in Metabolism and Medical & Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
Maheak VoraCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0009-0009-2645-4792
Alicia Huerta-ChagoyaDiabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0001-6218-3904
Jun WeiEndeavor Health, Evanston, IL, USA.
Ashley J MulfordEndeavor Health, Evanston, IL, USA.ORCID 0009-0003-0042-1358
Alan R SandersEndeavor Health, Evanston, IL, USA.ORCID 0000-0001-6629-4011
Jianfeng XuEndeavor Health, Evanston, IL, USA.
Liana K BillingsEndeavor Health, Evanston, IL, USA.ORCID 0000-0001-7991-3010
Bogdan PasaniucDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
David J CareyDepartment of Genomic Health, Geisinger, Danville, PA, USA.ORCID 0000-0001-6404-1950
Uyenlinh L MirshahiDepartment of Genomic Health, Geisinger, Danville, PA, USA.ORCID 0000-0003-4972-5451
Jose C FlorezDiabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-1730-9325
Alisa K ManningPrograms in Metabolism and Medical & Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.ORCID 0000-0003-0247-902X
Josep M MercaderDiabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0001-8494-3660
Miriam S UdlerDiabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0003-3824-9162
Aaron J DeutschDiabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0001-6750-5335

Funding

Diabetes-Docs: Physician-Scientist Career Development Program (DiabDocs)K12DK133995 · NIDDK · STANFORD UNIVERSITY · PI LINDA A DIMEGLIO, David Matthew Maahs · 2022 to 2026
$16.0M
Development of Polygenic Risk Scores for Diabetes and Complications across the Life-Span in Populations of Multiple AncestriesU01HG011723 · NHGRI · BROAD INSTITUTE, INC. · PI Alisa Knodle Manning, Josep Maria Mercader · 2021 to 2026
$5.7M
Multi-Ancestry Genetic Analysis of Type 1 Diabetes and Related ConditionsK23DK140643 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Aaron Jonathan Deutsch · 2024 to 2026
$576k
NHGRI NIH HHS U01 HG011723NIDDK NIH HHS K12 DK133995NIDDK NIH HHS K23 DK140643
6 · The paper itself

Abstract

Most polygenic scores (PS) for type 1 diabetes were developed using European (EUR) ancestry datasets, limiting performance in non-European (non-EUR) populations. We evaluated novel type 1 diabetes PS across diverse populations to assess whether newer models improve prediction in underrepresented populations. Seven type 1 diabetes PS (T1D GRS2, T1D GRS2', T1D GRS

Identifiers

PMID42818433
PMCPMC13622736

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.