ArticlebioRxiv : the preprint server for biology2026
Substrate Binding Relieves Autoinhibition of the Mammalian GCN2 Kinase.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Cells respond to amino acid starvation and translational stress through the integrated stress response (ISR) kinase GCN2. Current models maintain that GCN2 senses these stresses either by binding deacylated tRNAs that accumulate during amino acid starvation or by recognizing ribosome collisions that arise from perturbation of translation elongation. As tRNA charging is inherently coupled to translation elongation, assessing the relative contributions of these two pathways has proven difficult. To fully separate the roles of these potential agonists, we reconstituted the regulation of GCN2
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.