ArticlebioRxiv : the preprint server for biology2026
CypA is a molecular barrier to HIV emergence from Eastern chimpanzees.
Michael J Young, Fabricio Cotera, Clare C C Gill, Jacob A Lewis, Frank G Whitby, Alaa Abdel-Latif, Joana L Rocha, Michael Singer, Mike A Nalls, Faraz Faghri and 3 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
13 authors.
Michael J YoungDepartment of Molecular and Cell Biology, University of California Berkeley; Berkeley, CA, 94720, USA.ORCID 0000-0002-9167-2413 Fabricio CoteraDepartment of Molecular and Cell Biology, University of California Berkeley; Berkeley, CA, 94720, USA.
Clare C C GillDepartment of Molecular and Cell Biology, University of California Berkeley; Berkeley, CA, 94720, USA.ORCID 0009-0005-6689-702X Jacob A LewisDepartment of Biochemistry, University of Utah; Salt Lake City, UT, 84112, USA.
Alaa Abdel-LatifUniversity of California San Francisco Center for AIDS Research (CFAR); San Francisco, CA, 94143, USA.
Joana L RochaDepartment of Integrative Biology, University of California Berkeley; Berkeley, CA, 94720, USA.
Michael SingerDepartment of Molecular and Cell Biology, University of California Berkeley; Berkeley, CA, 94720, USA.
Mike A NallsCenter for Alzheimer's and Related Dementias, National Institute on Aging, National Institute of Neurological Disorders and Stroke, National Institutes of Health; Bethesda, MD, 20892, USA.
Faraz FaghriCenter for Alzheimer's and Related Dementias, National Institute on Aging, National Institute of Neurological Disorders and Stroke, National Institutes of Health; Bethesda, MD, 20892, USA.
Peter H SudmantDepartment of Molecular and Cell Biology, University of California Berkeley; Berkeley, CA, 94720, USA.ORCID 0000-0002-9573-8248 Molly OhainleDepartment of Molecular and Cell Biology, University of California Berkeley; Berkeley, CA, 94720, USA.ORCID 0000-0001-5138-5367 Funding
Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4MVirology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6MCHEETAH Center for the Structural Biology of HIV Infection, Restriction, and Viral DynamicsU54AI170856 · NIAID · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI WESLEY I. SUNDQUIST · 2022 to 2026
$34.4MLentiviral Restriction: capsid and beyondR01AI147877 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI Molly OhAinle · 2019 to 2026
$4.2MThe evolution and diversity of mutation, molecular fidelity, and genome structureR35GM142916 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Peter Heshedahl Sudmant · 2021 to 2026
$2.5MA compendium of complete primate reference genomes to facilitate conservation, genomics, and ecologyR01HG013017 · NHGRI · UNIVERSITY OF CALIFORNIA BERKELEY · PI Erik Garrison, Matthew William Mitchell · 2023 to 2026
$1.9MNCI NIH HHS P30 CA015704NHGRI NIH HHS R01 HG013017NIAID NIH HHS P30 AI027763NIAID NIH HHS R01 AI147877NIAID NIH HHS U54 AI170856NIGMS NIH HHS R35 GM142916
6 · The paper itselfAbstract
Of the two lineages of lentivirus that endemically infect chimpanzees, only one has served as a source of infections in humans. Using HIV-CRISPR screening, we identify factors that limit the replication of lentivirus from Eastern chimpanzees. We find that CypA restricts nonzoonotic Eastern chimpanzee lentivirus due to a unique feature encoded in capsid. The ability of CypA to restrict lentivirus replication is surprising given that CypA is a host factor exploited by HIV to promote its replication. The selective ability of CypA to restrict this virus provides a molecular explanation as to why lentivirus from Eastern Chimpanzees has never been observed to infect humans. Our work has important implications for understanding the origins of HIV-1 and the potential for novel zoonosis of primate lentiviruses.
Identifiers
PMID42818372
PMCPMC13622688
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