ArticlebioRxiv : the preprint server for biology2026
Translation fidelity mechanisms and their changes in aging.
Mauricio Aguilar Rangel, Casey Powers, Jaeyoon Lee, Haley E Tarbox, Neil B Wood, Stephen D Fried, Stephen Quake, Joseph D Puglisi
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
8 authors.
Mauricio Aguilar RangelDepartment of Structural Biology, Stanford University; Stanford, USA.
Casey PowersSUMS, Stanford University; Stanford, USA.
Jaeyoon LeeDepartment of Bioengineering, Stanford University; Stanford, USA.
Haley E TarboxDepartment of Chemistry, Johns Hopkins University; Baltimore, USA.
Neil B WoodT.C. Jenkins Department of Biophysics, Johns Hopkins University; Baltimore, USA.
Stephen D FriedDepartment of Chemistry, Johns Hopkins University; Baltimore, USA.
Stephen QuakeDepartment of Bioengineering, Stanford University; Stanford, USA.
Joseph D PuglisiDepartment of Structural Biology, Stanford University; Stanford, USA.
Funding
Research Training in Age-Related Cognitive DisordersT32AG027668 · NIA · JOHNS HOPKINS UNIVERSITY · PI MARILYN S. ALBERT · 2007 to 2026
$6.3MProgram of Molecular BiophysicsT32GM135131 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Karen G. Fleming · 2020 to 2026
$5.4MDynamics of TranslationR35GM145306 · NIGMS · STANFORD UNIVERSITY · PI JOSEPH D PUGLISI · 2022 to 2026
$3.8MThe Chemistry-Biology Interface Program at Johns Hopkins UniversityT32GM080189 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ROKITA, STEVEN E · 2008 to 2022
$3.5MDefining modifiers and mechanisms of RAN translationRF1AG064690 · NIA · STANFORD UNIVERSITY · PI GITLER, AARON D., PUGLISI, JOSEPH D · 2019 to 2019
$2.8MWatching Proteins Fold (or Misfold) in vivo with Mass SpectrometryDP2GM140926 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI FRIED, STEPHEN DAVID · 2020 to 2020
$2.3MDefining modifiers and mechanisms of RAN translationR01AG064690 · NIA · STANFORD UNIVERSITY · PI Aaron D. Gitler, JOSEPH D PUGLISI · 2024 to 2026
$2.3MNIA NIH HHS R01 AG064690NIA NIH HHS RF1 AG064690NIA NIH HHS T32 AG027668NIGMS NIH HHS DP2 GM140926NIGMS NIH HHS R35 GM145306NIGMS NIH HHS T32 GM080189NIGMS NIH HHS T32 GM135131
6 · The paper itselfAbstract
Protein errors (amino acid misincorporations) are associated to protein misfolding and misfunction, and lower levels correlate with longer lifespan
Identifiers
PMID42818343
PMCPMC13622271
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