ArticlebioRxiv : the preprint server for biology2026
Convergence and function of distinct corticocortical and transthalamic synapses across sensory processing hierarchies.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Communication among cortical regions underlies fundamental functions of the brain. Thus, it is essential to understand the synaptic mechanisms by which distinct cortical regions become functionally connected. While direct corticocortical synaptic connections between cortical regions have traditionally been considered the primary mode of cortex-wide interaction, these regions can also interact indirectly through transthalamic pathways that engage higher-order regions of the thalamus. Yet, the mechanisms by which these two distinct inter-cortical synaptic pathways exert their influence on their target cortical neurons are largely unknown. A major obstacle to the targeted synaptic analysis of these pathways has been the lack of an appropriate method to genetically label them, especially in the same preparation. Here, using a combination of viral vector methods for anterograde transsynaptic and retrograde labeling along with optogenetic activation of long-range synaptic terminals in
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