Evidence map›Paper›PMID 42818327›Full record

ArticlebioRxiv : the preprint server for biology2026

Temporal control of mitochondrial mutagenesis reveals the fate of mtDNA mutations with age.

Sarah J Shemtov, Eric Hwang, Claire S Chung, Herbert Anson, Lucy Carrillo, Sangmin Lee, Ivetta Vorobyova, Junxiang Wan, Scott R Kennedy, Amy R Vandiver and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Sarah J ShemtovLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-8176-1105
Eric HwangLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Claire S ChungLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Herbert AnsonLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Lucy CarrilloLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Sangmin LeeLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Ivetta VorobyovaMolecular Imaging Center, Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Junxiang WanLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Scott R KennedyDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-4444-1145
Amy R VandiverDivision of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA.ORCID 0000-0003-2176-9161
Bert M VerheijenDepartment of Systems Biology, Harvard Medical School, Boston, MA, USA.
Whitaker CohnAlfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA, USA.
Bérénice A BenayounLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-7401-4777
Max A ThorwaldLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Pinchas CohenLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Jonathan WanagatDivision of Geriatrics, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA.ORCID 0000-0002-8460-8616
Jean-François GoutDepartment of Biological Sciences, Mississippi State University, Starkville, MS, USA.
Marc VermulstLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.

Funding

Investigating the landscape and genetic architecture of germline mutagenesisR35GM133428 · NIGMS · UNIVERSITY OF WASHINGTON · PI Kelley Harris · 2019 to 2026
$2.8M
Temporal control of mitochondrial mutagenesisR01AG075130 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Marc Vermulst · 2022 to 2026
$2.6M
DNA-damage-induced transcription errors provide a constant stream of amyloid and prion-like proteins in human cellsR01AG083065 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Marc Vermulst · 2024 to 2026
$2.1M
Targeting the IGF-1/insulin signaling pathway to treat mtDNA diseaseR01GM124532 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VERMULST, MARC · 2017 to 2020
$1.2M
Triggering the Selective Removal of Deleterious mtDNA Mutations from Mammalian CellsF31AG084238 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SHEMTOV, SARAH JEAN · 2024 to 2024
$49k
NIA NIH HHS F31 AG084238NIA NIH HHS R01 AG075130NIA NIH HHS R01 AG083065NIGMS NIH HHS R01 GM124532NIGMS NIH HHS R35 GM133428
6 · The paper itself

Abstract

Mutations in the mitochondrial genome (mtDNA) play a critical role in the aging process and a wide variety of age-related diseases. However, it remains unclear when the mutations that drive physiological decline arise. To answer this question, we generated a new mouse model in which mitochondrial mutagenesis can be confined to a defined window of time. Surprisingly, we found that mutations that arise during the first two months of life are sufficient to drive a wide variety of age-related pathologies, and that the severity of this pathology is broadly regulated by distinct, tissue-specific selective pressures that control the fate of mtDNA mutations with age. Further, we found that selection against deleterious variants can be modulated by manipulation of mitochondrial fusion

Identifiers

PMID42818327
PMCPMC13622244

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.