Evidence map›Paper›PMID 42818292›Full record

ArticlebioRxiv : the preprint server for biology2026

Clonal hematopoiesis-associated DNMT3A mutations derepress bivalent Polycomb target genes and enhance macrophage migration.

Yuri Lee, Philip K Farahat, Jennifer P Nguyen, Yoshiko Takahashi, Jung-Yeon Lim, Xin Huang, Camille Brzechffa, Marie E S Wheeler, Hye-Ju Yang, Jihye Lee and 14 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Yuri LeeDepartment of Microbiology and Molecular Genetics, University of California, Irvine, CA, USA.
Philip K FarahatDepartment of Physiology and Biophysics, University of California, Irvine, CA, USA.
Jennifer P NguyenCenter for Epigenetics and Metabolism, University of California, Irvine, CA, USA.
Yoshiko TakahashiDepartment of Microbiology and Molecular Genetics, University of California, Irvine, CA, USA.
Jung-Yeon LimPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Xin HuangDivision of Hematology/Oncology, Department of Medicine, University of California, Irvine, Irvine, CA, USA.
Camille BrzechffaDivision of Hematology/Oncology, Department of Medicine, University of California, Irvine, Irvine, CA, USA.
Marie E S WheelerDepartment of Microbiology and Molecular Genetics, University of California, Irvine, CA, USA.
Hye-Ju YangDepartment of Microbiology and Molecular Genetics, University of California, Irvine, CA, USA.
Jihye LeePrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Zachary S PopeDepartment of Microbiology and Molecular Genetics, University of California, Irvine, CA, USA.
Daniella J LuDepartment of Microbiology and Molecular Genetics, University of California, Irvine, CA, USA.
Akshata N RudrapatnaDivisions of Immunobiology, and Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Alec P PankowDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Xiaoting ChenCenter for Autoimmune Genomics and Etiology, Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Hongseok YunDepartment of Genomic Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Matthew T WeirauchDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Ivan MarazziCenter for Epigenetics and Metabolism, University of California, Irvine, CA, USA.
Brad R RosenbergDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Emily R MiraldiDivisions of Immunobiology, and Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Eirini P PapapetrouDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
S Armando VillaltaDepartment of Physiology and Biophysics, University of California, Irvine, CA, USA.
Angela G FleischmanDivision of Hematology/Oncology, Department of Medicine, University of California, Irvine, Irvine, CA, USA.
Minji ByunDepartment of Microbiology and Molecular Genetics, University of California, Irvine, CA, USA.ORCID 0000-0002-2830-4079

Funding

Tissue Repository CoreP30AR070549 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI Leah Claire Kottyan · 2016 to 2026
$7.7M
Altered inflammatory response associated with acquired DNMT3A mutationsR01HL153974 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI BYUN, MINJI · 2021 to 2025
$3.3M
Gene regulatory network modeling of disease-associated DNA methylation perturbationsR01AI173314 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI Minji Byun, Emily Miraldi · 2023 to 2026
$3.1M
Mechanistic modeling of epigenetic modifier mutations in human pluripotent stem cell-derived immune cellsR21AI164367 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI BYUN, MINJI · 2022 to 2023
$450k
NHLBI NIH HHS R01 HL153974NIAID NIH HHS R01 AI173314NIAID NIH HHS R21 AI164367NIAMS NIH HHS P30 AR070549
6 · The paper itself

Abstract

Somatic mutations in the de novo DNA methyltransferase

Identifiers

PMID42818292
PMCPMC13622240

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.