Evidence map›Paper›PMID 42818271›Full record

ArticlebioRxiv : the preprint server for biology2026

Pyroptotic cell-derived factors promote osteoclast differentiation.

Yongjia Li, Chun Wang, Canxin Xu, Wei Zou, Khushpreet Kaur, Ria Rohatgi, Nitin Pokhrel, Nidhi Rohatgi, Yousef Abu-Amer, Gabriel Mbalaviele

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yongjia LiDivision of Bone and Mineral Diseases, Washington University School of Medicine; St. Louis, MO 63110, USA.
Chun WangDivision of Bone and Mineral Diseases, Washington University School of Medicine; St. Louis, MO 63110, USA.
Canxin XuAclaris Therapeutics Inc., St. Louis, MO 63108, USA.
Wei ZouDivision of Bone and Mineral Diseases, Washington University School of Medicine; St. Louis, MO 63110, USA.
Khushpreet KaurDivision of Bone and Mineral Diseases, Washington University School of Medicine; St. Louis, MO 63110, USA.
Ria RohatgiDivision of Bone and Mineral Diseases, Washington University School of Medicine; St. Louis, MO 63110, USA.
Nitin PokhrelDivision of Bone and Mineral Diseases, Washington University School of Medicine; St. Louis, MO 63110, USA.
Nidhi RohatgiDivision of Bone and Mineral Diseases, Washington University School of Medicine; St. Louis, MO 63110, USA.
Yousef Abu-AmerDepartment of Orthopedic Surgery, Washington University School of Medicine; St. Louis, MO 63110, USA.
Gabriel MbalavieleDivision of Bone and Mineral Diseases, Washington University School of Medicine; St. Louis, MO 63110, USA.

Funding

Resource Based Center for Musculoskeletal Biology and Medicine (Overall Application)P30AR074992 · NIAMS · WASHINGTON UNIVERSITY · PI MATTHEW J SILVA · 2019 to 2026
$6.8M
Differential Inflammasome Regulation in the pathogenesis of S. aureus osteomyelitisR01AI161022 · NIAID · WASHINGTON UNIVERSITY · PI CASSAT, JAMES E, MBALAVIELE, GABRIEL · 2021 to 2025
$3.4M
Molecular pathways of calcium pyrophosphate deposition diseaseR01AG077732 · NIA · MEDICAL COLLEGE OF WISCONSIN · PI Gabriel Mbalaviele, Ann K Rosenthal · 2022 to 2026
$2.4M
Development of Injectable Super-Lubricious Microgels for Sustained Release of Platelet-Rich Plasma to Treat Post-Traumatic OsteoarthritisR01AR081270 · NIAMS · SAINT LOUIS UNIVERSITY · PI Yousef Abu-Amer, Silviya Petrova Zustiak · 2023 to 2026
$2.1M
Regulation of Osteoclastogenesis and Inflammatory OsteolysisR01AR082192 · NIAMS · WASHINGTON UNIVERSITY · PI Yousef Abu-Amer · 2023 to 2026
$1.9M
NIAID NIH HHS R01 AI161022NIAMS NIH HHS P30 AR074992NIAMS NIH HHS R01 AR081270NIAMS NIH HHS R01 AR082192NIA NIH HHS R01 AG077732
6 · The paper itself

Abstract

The NLRP3 D301N substitution, the murine ortholog of the human D303N variant, causes NLRP3 constitutive activation (NLRP3

Identifiers

PMID42818271
PMCPMC13622540

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.