Evidence map›Paper›PMID 42818256›Full record

ArticlebioRxiv : the preprint server for biology2026

Translation of a small upstream open reading frame functions as a rheostat for the regulation of

Caroline A Spike, Micah D Gearhart, Katherine M Walstrom, Mark E Zweifel, Naomi Courtemanche, David Greenstein

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Caroline A SpikeDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0001-5067-7472
Micah D GearhartDepartment of Obstetrics, Gynecology, and Women's Health, University of Minnesota Medical School, Minneapolis, MN 55455, USA.ORCID 0000-0002-9873-1930
Katherine M WalstromDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-8896-3850
Mark E ZweifelDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0009-0006-7980-8783
Naomi CourtemancheDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0003-4374-4782
David GreensteinDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0001-8189-2087

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Molecular mechanisms of bundled actin structure assembly by forminsR01GM122787 · NIGMS · UNIVERSITY OF MINNESOTA · PI Naomi Courtemanche · 2017 to 2026
$2.7M
The C. elegans Germline: A Test Tube for Cell and Developmental BiologyR35GM144029 · NIGMS · UNIVERSITY OF MINNESOTA · PI David Irwin Greenstein · 2022 to 2026
$2.1M
Epigenetic Control of Trophoblast DifferentiationR01HD120295 · NICHD · UNIVERSITY OF MINNESOTA · PI Micah Gearhart · 2026 to 2026
$644k
NICHD NIH HHS R01 HD120295NIGMS NIH HHS R01 GM122787NIGMS NIH HHS R35 GM144029NIH HHS P40 OD010440
6 · The paper itself

Abstract

MicroRNAs have been likened to the "dark matter" of eukaryotic genomes, reflecting their pervasive regulatory influence. MicroRNAs were first identified through genetic studies of developmental timing in the nematode

Indexed as

developmental timingMicroRNA regulationtranslational controlupstream open reading frame

Identifiers

PMID42818256
PMCPMC13622164

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.