Evidence map›Paper›PMID 42818229›Full record

ArticlebioRxiv : the preprint server for biology2026

Conservation of Nuclear Receptor DAF-12 with Evidence for Ligand Diversification in Plant-Parasitic Nematodes.

Yanjie Liu, Chih-Wei Fan, Zhu Wang, George Wendt, Lauren G Zacharias, Jeffrey G McDonald, Yunhai Li, Shi-Yi Shen, H Eric Xu, James J Collins and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yanjie LiuDepartment of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Chih-Wei FanDepartment of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Zhu WangDepartment of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
George WendtDepartment of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Lauren G ZachariasChildren's Medical Center Research Institute, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Jeffrey G McDonaldCenter for Human Nutrition, Department of Molecular Genetics, UT Southwestern Medical Center, Dallas, TX, USA.
Yunhai LiState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Shi-Yi ShenState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
H Eric XuState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
James J CollinsDepartment of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Steven KliewerDepartment of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0001-5161-641X
Melissa G MitchumDepartment of Plant Pathology and Institute of Plant Breeding, Genetics and Genomics, University of Georgia, Athens, GA 30602, USA.
David J MangelsdorfDepartment of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Thomas P MathewsCenter for Human Nutrition, Department of Molecular Genetics, UT Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-6829-8144

Funding

Drug Target Discovery, Validation, and Prioritization for SchistosomiasisR01AI167967 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI James J Collins, Margaret A. Phillips · 2023 to 2026
$3.3M
NIAID NIH HHS R01 AI167967
6 · The paper itself

Abstract

Plant-parasitic nematodes cause extensive crop losses that threaten global food security and create substantial economic hardship, yet strategies for their control remain limited. Although plant-parasitic nematodes have life cycles that mirror those of their free-living and animal-parasitic relatives, comparatively little is known about the signals that drive life-cycle progression. Dafachronic acids (DAs) are steroid hormones that control life cycle by activating DAF-12 nuclear receptors in

Indexed as

DAF-12dafachronic acidHeterodera glycinesligandnuclear receptorplant-parasitic nematodessoybean cyst nematode

Identifiers

PMID42818229
PMCPMC13622478

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.