Evidence map›Paper›PMID 42818226›Full record

ArticlebioRxiv : the preprint server for biology2026

GTP biosynthesis is a therapeutic vulnerability in Rac1-mutant melanoma.

Samson Eugin Simon, Tiannan Wang, Arsha Sreekumar, Zaria Yearby, Isha Patel, Varsha Tandra, Catherine C Hedrick, Jie Li, David W Wolff

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Samson Eugin SimonGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA.ORCID 0000-0003-0710-3857
Tiannan WangGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA.
Arsha SreekumarGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA.
Zaria YearbyGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA.
Isha PatelGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA.
Varsha TandraVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA.
Catherine C HedrickGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA.
Jie LiVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA.
David W WolffGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA.ORCID 0000-0003-4201-3857

Funding

The Impact of Obesity and Leptin on the Development of Immune System Dysfunction and Hypertension in Females with Systemic Lupus ErythematousU54HL169191 · NHLBI · AUGUSTA UNIVERSITY · PI Daria Ilatovskaya · 2023 to 2026
$7.4M
Wrestling stress: role of ufm1 modification in pathological cardiac remodelingR01HL146807 · NHLBI · AUGUSTA UNIVERSITY · PI Jie Li · 2020 to 2026
$2.7M
Interrogating the role of GTP metabolism in Rac1-driven phenotypes in melanomaR00CA266920 · NCI · AUGUSTA UNIVERSITY · PI David W Wolff · 2024 to 2026
$733k
NCI NIH HHS R00 CA266920NHLBI NIH HHS R01 HL146807NHLBI NIH HHS U54 HL169191
6 · The paper itself

Abstract

Metastatic melanoma remains highly lethal despite advances in immunotherapy and MAPK-targeted therapy. The Rac1

Identifiers

PMID42818226
PMCPMC13622192

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.