Evidence map›Paper›PMID 42818209›Full record

ArticlebioRxiv : the preprint server for biology2026

β-Lactam antibiotics trigger mouse TLR2/4- and human TLR2/5-dependent Jarisch-Herxheimer reaction in leptospirosis.

Stylianos Papadopoulos, Thomas Bernard, Dorian Joffres, Frédérique Vernel-Pauillac, Julie Cagliero, COSIPOP study group, Catherine Werts

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Stylianos PapadopoulosInstitut Pasteur, Université Paris Cité, INSERM U1306, Unité de Biologie et Génétique de la Paroi Bactérienne, Paris, F-75015, France.ORCID 0009-0004-2611-9832
Thomas BernardInstitut Pasteur, Université Paris Cité, INSERM U1306, Unité de Biologie et Génétique de la Paroi Bactérienne, Paris, F-75015, France.ORCID 0000-0002-9945-4285
Dorian JoffresInstitut Pasteur, Université Paris Cité, INSERM U1306, Unité de Biologie et Génétique de la Paroi Bactérienne, Paris, F-75015, France.
Frédérique Vernel-PauillacInstitut Pasteur, Université Paris Cité, INSERM U1306, Unité de Biologie et Génétique de la Paroi Bactérienne, Paris, F-75015, France.ORCID 0000-0002-3188-9039
Julie CaglieroInstitut Pasteur, Université Paris Cité, INSERM U1306, Unité de Biologie et Génétique de la Paroi Bactérienne, Paris, F-75015, France.ORCID 0000-0002-8476-2680
COSIPOP study group
Catherine WertsInstitut Pasteur, Université Paris Cité, INSERM U1306, Unité de Biologie et Génétique de la Paroi Bactérienne, Paris, F-75015, France.ORCID 0000-0003-3079-5476

Funding

Virulence and Adaptation to the Host Environment of Pathogenic LeptospiraP01AI168148 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DAVID A HAAKE · 2023 to 2026
$11.8M
NIAID NIH HHS P01 AI168148
6 · The paper itself

Abstract

Leptospirosis is a neglected zoonotic disease causing ~1 million cases and 60,000 deaths annually. Antibiotic therapy can trigger a detrimental inflammatory Jarisch-Herxheimer reaction (JHR). We investigated antibiotic effects in leptospirosis, using a mouse model of severe disease and human whole blood from healthy donors infected ex vivo with bioluminescent

Indexed as

AmoxicillinCeftriaxoneCytokinesCytokine stormHuman bloodInflammationInnate immunityJarisch-Herxheimer reactionLeptospirosisOne healthSpirochetesToll-like receptorsβ-Lactam antibiotics

Identifiers

PMID42818209
PMCPMC13622424

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.