ArticlemedRxiv : the preprint server for health sciences2026
A founder population reveals genetic variation with major effect on serious mental illness.
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In one paragraph
Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
59 authors.
Greta GerdesCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California, USA.ORCID 0009-0009-8348-8550
Veronica TozzoDepartment of Computational Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.ORCID 0000-0001-8538-9198
Susan K ServiceCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California, USA.ORCID 0009-0003-4686-2466
Clara Frydman-GaniCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California, USA.ORCID 0009-0000-9025-3690
Ana M Diaz-ZuluagaCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California, USA.
Johanna Valencia-EcheverryResearch Group in Psychiatry, Department of Psychiatry, School of Medicine, Universidad de Antioquia, Medellín, Antioquia, Colombia.
Alejandro AriasResearch Group in Psychiatry, Department of Psychiatry, School of Medicine, Universidad de Antioquia, Medellín, Antioquia, Colombia.
Lucy K BicksProgram in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-9884-0133
Ana M Ramirez-DiazCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California, USA.
Julia M SealockAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-9346-3498
Calwing LiaoAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0001-6169-7137
Daniel P HowriganAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-7721-4838
Christiana LiuStanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.ORCID 0009-0001-2078-651X
Esteban A Lopera-MayaCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California, USA.ORCID 0000-0001-5862-3938
Aditya PimplaskarCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California, USA.ORCID 0000-0002-5660-7210
Juan F De la HozCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California, USA.ORCID 0000-0002-5584-7511
Mario A Arango-GómezResearch Group in Psychiatry, Department of Psychiatry, School of Medicine, Universidad de Antioquia, Medellín, Antioquia, Colombia.
Camila Arango-RestrepoResearch Group in Psychiatry, Department of Psychiatry, School of Medicine, Universidad de Antioquia, Medellín, Antioquia, Colombia.
Maria C Arbelaez-HerreraResearch Group in Psychiatry, Department of Psychiatry, School of Medicine, Universidad de Antioquia, Medellín, Antioquia, Colombia.
Katherine Camacho-GualterosResearch Group in Psychiatry, Department of Psychiatry, School of Medicine, Universidad de Antioquia, Medellín, Antioquia, Colombia.
Mateo Cardona-ArangoResearch Group in Psychiatry, Department of Psychiatry, School of Medicine, Universidad de Antioquia, Medellín, Antioquia, Colombia.
Mauricio Castaño-RamirezDepartment of Mental Health and Human Behavior, Universidad de Caldas, Colombia.
Jaime A Castañeda-HoyosData Engineering Lead, Center for Biosciences, SURA, Colombia.
Felecia CerratoStanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.ORCID 0000-0002-9086-7710
Sinéad B ChapmanStanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Roby E Franco-GómezResearch Group in Psychiatry, Department of Psychiatry, School of Medicine, Universidad de Antioquia, Medellín, Antioquia, Colombia.ORCID 0000-0002-0230-058X
John D Londoño-MartinezResearch Group in Psychiatry, Department of Psychiatry, School of Medicine, Universidad de Antioquia, Medellín, Antioquia, Colombia.
John S Mazo-MoralesResearch Group in Psychiatry, Department of Psychiatry, School of Medicine, Universidad de Antioquia, Medellín, Antioquia, Colombia.
Juan C Mejía-PiedrahitaResearch Group in Psychiatry, Department of Psychiatry, School of Medicine, Universidad de Antioquia, Medellín, Antioquia, Colombia.
Emaad MirCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California, USA.
Tyler M MooreDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Luz E Perez-JaramilloDirector of Epidemiology and Data Science, Center for Biosciences, SURA, Colombia.
Maria Pérez-VallejoResearch Group in Psychiatry, Department of Psychiatry, School of Medicine, Universidad de Antioquia, Medellín, Antioquia, Colombia.
Maria E Posada-RicardoResearch Group in Psychiatry, Department of Psychiatry, School of Medicine, Universidad de Antioquia, Medellín, Antioquia, Colombia.
Vladimir Riscanevo-PosadaResearch Group in Psychiatry, Department of Psychiatry, School of Medicine, Universidad de Antioquia, Medellín, Antioquia, Colombia.
Camila Restrepo-OsorioResearch Group in Psychiatry, Department of Psychiatry, School of Medicine, Universidad de Antioquia, Medellín, Antioquia, Colombia.
Daniela Restrepo-OsorioResearch Group in Psychiatry, Department of Psychiatry, School of Medicine, Universidad de Antioquia, Medellín, Antioquia, Colombia.
Kosha RuparelNeurodevelopment and Psychosis Section, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-9274-4303
Danilo Sánchez-PatiñoResearch Group in Psychiatry, Department of Psychiatry, School of Medicine, Universidad de Antioquia, Medellín, Antioquia, Colombia.
Terri TeshibaCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California, USA.
Jonathan ValdezCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California, USA.
Wendy Valencia-LondoñoResearch Group in Psychiatry, Department of Psychiatry, School of Medicine, Universidad de Antioquia, Medellín, Antioquia, Colombia.
Oscar A Valencia-ZuluagaResearch Group in Psychiatry, Department of Psychiatry, School of Medicine, Universidad de Antioquia, Medellín, Antioquia, Colombia.
Jorge M Velez-ArangoCenter for Biosciences, SURA, Colombia.
Nicolas A CrossleyResearch Group in Psychiatry, Department of Psychiatry, School of Medicine, Universidad de Antioquia, Medellín, Antioquia, Colombia.ORCID 0000-0002-3060-656X
Juan David Palacio-OrtizResearch Group in Psychiatry, Department of Psychiatry, School of Medicine, Universidad de Antioquia, Medellín, Antioquia, Colombia.
Daniel H GeschwindProgram in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-2896-3450
Alicia R MartinAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0003-0241-3522
Ruben C GurLifespan Brain Institute (LiBI) of Penn Medicine and CHOP, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-9657-1996
Michael R SawayaDepartment of Biological Chemistry, University of California, Los Angeles, CA, USA.
David S EisenbergDepartment of Biological Chemistry, University of California, Los Angeles, CA, USA.
Javier I EscobarRutgers University, New Brunswick, NJ, USA.
Chiara SabattiDepartment of Biomedical Data Science, Stanford, CA, USA.ORCID 0000-0001-5829-9058
Victor I ReusDepartment of Psychiatry and Behavioral Sciences, School of Medicine, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0002-8193-5697
Carrie E BeardenCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California, USA.ORCID 0000-0002-8516-923X
Benjamin M NealeBD2: Breakthrough Discoveries for Thriving with Bipolar Disorder, Santa Monica, California, USA.ORCID 0000-0003-1513-6077
Carlos Lopez-JaramilloBD2: Breakthrough Discoveries for Thriving with Bipolar Disorder, Santa Monica, California, USA.ORCID 0000-0002-1875-1369
Nelson B FreimerCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California, USA.ORCID 0000-0003-3586-6587
Loes M Olde LoohuisCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California, USA.ORCID 0000-0002-3327-7837
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M1/4 Powering Genetic Discovery for Severe Mental Illness in Latin American and African AncestriesU01MH125047 · NIMH · BROAD INSTITUTE, INC. · PI MARTIN, ALICIA, NEALE, BENJAMIN MICHAEL · 2020 to 2024
$11.5MA Latin American biobank for large-scale genetics research on severe mental illnessR01MH123157 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FREIMER, NELSON B., LOPEZ JARAMILLO, CARLOS · 2020 to 2025
$10.6MStatistical methods for studies of rare variantsR01MH101244 · NIMH · HARVARD MEDICAL SCHOOL · PI Benjamin Michael Neale, ALKES L PRICE · 2013 to 2026
$9.4MGenetics of Severe Mental IllnessR01MH113078 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E, FREIMER, NELSON B. · 2017 to 2021
$5.8M4/4 Powering Genetic Discovery for Severe Mental Illness in Latin American and African AncestriesU01MH125042 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FREIMER, NELSON B., LOPEZ JARAMILLO, CARLOS · 2020 to 2024
$5.3MMental Health Genomics Consortium Coordinating CenterU24MH140953 · NIMH · BROAD INSTITUTE, INC. · PI Hailiang Huang, Alicia Martin · 2026 to 2026
$2.4MNCATS NIH HHS UL1 TR001881NIMH NIH HHS R01 MH101244NIMH NIH HHS R01 MH113078NIMH NIH HHS R01 MH123157NIMH NIH HHS U01 MH125042NIMH NIH HHS U01 MH125047NIMH NIH HHS U24 MH140953
Abstract
Genetic studies of serious mental illness (SMI, including schizophrenia and bipolar disorder) have implicated two classes of risk variant: common variants
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