Evidence map›Paper›PMID 42818132›Full record

ArticlebioRxiv : the preprint server for biology2026

Inhibitory Fc Receptor sets a time limit on macrophage response to IgG.

Annalise Bond, Erika T Snyder, Andrew Manion, Catherine Hardy, Kenny Kieu, Maxwell Z Wilson, Enoch Yeung, Meghan A Morrissey

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Annalise BondMolecular Cellular and Developmental Biology Department, University of California; Santa Barbara, Santa Barbara, CA, USA.ORCID 0000-0001-5300-8151
Erika T SnyderMolecular Cellular and Developmental Biology Department, University of California; Santa Barbara, Santa Barbara, CA, USA.ORCID 0009-0005-8850-0687
Andrew ManionMolecular Cellular and Developmental Biology Department, University of California; Santa Barbara, Santa Barbara, CA, USA.ORCID 0009-0007-5031-2888
Catherine HardyMolecular Cellular and Developmental Biology Department, University of California; Santa Barbara, Santa Barbara, CA, USA.ORCID 0009-0003-9181-6012
Kenny KieuMolecular Cellular and Developmental Biology Department, University of California; Santa Barbara, Santa Barbara, CA, USA.ORCID 0009-0001-5751-231X
Maxwell Z WilsonMolecular Cellular and Developmental Biology Department, University of California; Santa Barbara, Santa Barbara, CA, USA.ORCID 0000-0003-0768-7004
Enoch YeungDepartment of Mechanical Engineering, University of California, Santa Barbara; Santa Barbara, CA, USA.ORCID 0000-0001-7630-7429
Meghan A MorrisseyMolecular Cellular and Developmental Biology Department, University of California; Santa Barbara, Santa Barbara, CA, USA.ORCID 0000-0002-0531-4864

Funding

MARC at the University of California Santa BarbaraT34GM136466 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI Arica Ayalah Lubin, Joel H. Rothman · 2020 to 2026
$2.7M
Signal Integration during PhagocytosisR35GM146935 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI Meghan A Morrissey · 2022 to 2026
$1.9M
Dissecting the structure-function relationship of the Wnt destruction complex condensateR21CA301306 · NCI · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI WILSON, MAXWELL ZANE · 2025 to 2025
$402k
NCI NIH HHS R21 CA301306NIGMS NIH HHS R35 GM146935NIGMS NIH HHS T34 GM136466
6 · The paper itself

Abstract

Antibodies engage both activating Fc Receptors and the inhibitory receptor FcγRIIB. Why macrophages need a dedicated inhibitory receptor rather than simply tuning activating receptor signaling is unclear. Using DNA-based chimeric receptors and in silico modeling, we independently controlled activating and inhibitory Fc Receptors. We found that FcγRIIB imposed a time limit on macrophage phagocytosis and ERK signaling. The time limit is due to activating Fc Receptors converting PI(4,5)P2 to PI(3,4,5)P3, which is subsequently converted to PI(3,4)P2 by FcγRIIB. This leads to a pulse of active signaling, which is sufficient for phagocytosis of small bacteria-sized targets but not phagocytosis of large targets and TNFα secretion. Unlike engaging FcγRIIB, reducing activating Fc Receptor signaling decreased initiation of phagocytosis, the speed of PI(3,4,5)P3 generation, and the amplitude of ERK signaling. Our results demonstrate that FcγRIIB controls the duration of IgG signaling, while the activating Fc Receptors control sensitivity.

Indexed as

Fc ReceptorsFcγRIIBIgGInflammationInhibitory ReceptorsMacrophage SignalingPhagocytosisSignal Integration

Identifiers

PMID42818132
PMCPMC13622107

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.