Evidence map›Paper›PMID 42818113›Full record

ArticlebioRxiv : the preprint server for biology2026

Axonal entry and retrograde transport define HSV-1 latency establishment and reactivation potential in neurons.

Christina Pantoja, Audrey D Loaiza, Khanh T Y Luong, Orkide O Koyuncu

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Christina PantojaDepartment of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, CA 92697.ORCID 0000-0002-9363-1412
Audrey D LoaizaDepartment of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, CA 92697.
Khanh T Y LuongDepartment of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, CA 92697.
Orkide O KoyuncuDepartment of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, CA 92697.ORCID 0000-0003-4038-9391

Funding

The Role of Interferon Lambda in Alpha Herpesvirus NeuroinvasionR01AI185349 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI Orkide O. Koyuncu · 2025 to 2026
$957k
Neuroimmunology Training Program at the University of California, IrvineT32NS121727 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Kim Green, Thomas E Lane · 2022 to 2026
$854k
The UC Irvine Center for Neural Circuit Mapping training program in Alzheimer's disease researchT32AG081185 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Todd C Holmes, XIANGMIN XU · 2024 to 2026
$833k
Establishing a Laboratory Model of Herpes simplex virus (HSV) Latency Using Compartmented Neuron CulturesR21AI144492 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI KOYUNCU, ORKIDE O. · 2020 to 2021
$438k
NIAID NIH HHS R01 AI185349NIAID NIH HHS R21 AI144492NIA NIH HHS T32 AG081185NINDS NIH HHS T32 NS121727
6 · The paper itself

Abstract

Herpes simplex virus 1 (HSV-1) establishes life-long latency in peripheral neurons following neuroinvasion, yet the early determinants governing latency versus productive infection remain poorly understood. Available

Indexed as

axonal infectionHSV-1 latencyreactivationretrograde infection

Identifiers

PMID42818113
PMCPMC13622258

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.