Evidence map›Paper›PMID 42818092›Full record

ArticlebioRxiv : the preprint server for biology2026

Hopeaphenol targets histidine kinase signaling across kingdoms to suppress bacterial virulence and potentiate plant immunity.

Jieun Kang, Nayeon Yoo, Talia Karasov, Venkatesh P Thirumlaikumar, Lydia Story, Eui-Hwan Chung, Aleksandra Skirycz

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jieun KangDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0002-1455-8641
Nayeon YooDepartment of Plant Biotechnology, Korea University, Seoul, Republic of Korea.
Talia KarasovSchool of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-3592-6597
Venkatesh P ThirumlaikumarPurdue University, West Lafayette, IN 47907, USA.
Lydia StoryDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA.
Eui-Hwan ChungDepartment of Plant Biotechnology, Korea University, Seoul, Republic of Korea.
Aleksandra SkiryczDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0002-7627-7925

Funding

Protein-metabolite interaction networks for functional characterization of metabolites.R35GM153298 · NIGMS · MICHIGAN STATE UNIVERSITY · PI Aleksandra Skirycz · 2024 to 2026
$1.2M
NIGMS NIH HHS R35 GM153298
6 · The paper itself

Abstract

Small molecules can control plant disease either by disarming the pathogen or by priming host immunity, but single compounds that do both are rare and mechanistically unexplained. Here we show that hopeaphenol (HP), a resveratrol tetramer from stilbene-producing plants, acts on histidine kinase (HK) signaling on both sides of the Arabidopsis-

Indexed as

cytokinin receptorhistidine kinaseHopeaphenolimmune responsetype III secretion system

Identifiers

PMID42818092
PMCPMC13622298

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.