Evidence map›Paper›PMID 42818087›Full record

ArticlebioRxiv : the preprint server for biology2026

An Excelled Trifluorinated Probe for GPCR Conformational Quantification.

Xudong Wang, Yulong Cao, Wenjie Zhao, Wenkai Sun, Trang Ma, Yongbo Zhang, Libin Ye

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xudong WangDepartment of Molecular Biosciences, University of South Florida, 4202 E Fowler Ave, Tampa, FL, USA 33620.
Yulong CaoDepartment of Molecular Biosciences, University of South Florida, 4202 E Fowler Ave, Tampa, FL, USA 33620.
Wenjie ZhaoDepartment of Molecular Biosciences, University of South Florida, 4202 E Fowler Ave, Tampa, FL, USA 33620.
Wenkai SunDepartment of Molecular Biosciences, University of South Florida, 4202 E Fowler Ave, Tampa, FL, USA 33620.
Trang MaDepartment of Molecular Biosciences, University of South Florida, 4202 E Fowler Ave, Tampa, FL, USA 33620.
Yongbo ZhangDepartment of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL, USA 60208.
Libin YeDepartment of Molecular Biosciences, University of South Florida, 4202 E Fowler Ave, Tampa, FL, USA 33620.ORCID 0000-0003-0818-2972

Funding

The Role of Intermediate Conformations in G Protein-coupled Receptor SignalingR01GM149659 · NIGMS · UNIVERSITY OF SOUTH FLORIDA · PI Libin Ye · 2023 to 2026
$1.4M
The Role of G Protein-coupled Receptors in Red Tide Dinoflagellate BioluminescenceR21ES035378 · NIEHS · UNIVERSITY OF SOUTH FLORIDA · PI YE, LIBIN · 2023 to 2023
$407k
NIEHS NIH HHS R21 ES035378NIGMS NIH HHS R01 GM149659
6 · The paper itself

Abstract

G protein-coupled receptors (GPCRs) represent the largest membrane protein family in the human body and the major targets of FDA-approved medications. Unlike some other physiological proteins, GPCRs are highly plastic and often exist as collections of conformational ensembles in the environment to exert their function. Therefore, understanding how a GPCR adopts different conformational ensembles in response to ligands and signaling partners is essential for drug development.

Identifiers

PMID42818087
PMCPMC13622042

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.