Evidence map›Paper›PMID 42818070›Full record

ArticlebioRxiv : the preprint server for biology2026

Human memory CD4

Vinicius G Suzart, Robert Schauner, Scott M Reba, Daniel P Gail, Gwendolyn Swarbrick, David M Lewinsohn, Deborah A Lewinsohn, Bianca Lepe, Bryan D Bryson, Samuel M Behar and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Vinicius G SuzartDivision of Infectious Diseases and HIV Medicine, Department of Medicine, Cleveland, OH, USA.
Robert SchaunerDivision of Infectious Diseases and HIV Medicine, Department of Medicine, Cleveland, OH, USA.
Scott M RebaDivision of Infectious Diseases and HIV Medicine, Department of Medicine, Cleveland, OH, USA.
Daniel P GailDivision of Infectious Diseases and HIV Medicine, Department of Medicine, Cleveland, OH, USA.
Gwendolyn SwarbrickPortland VA Medical Center, Portland, Oregon, USA.
David M LewinsohnPortland VA Medical Center, Portland, Oregon, USA.
Deborah A LewinsohnMolecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon, USA.
Bianca LepeDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Bryan D BrysonDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0003-1716-6712
Samuel M BeharDepartment of Microbiology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-3374-6699
Christopher M SassettiDepartment of Microbiology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Michael L FreemanDivision of Infectious Diseases and HIV Medicine, Department of Medicine, Cleveland, OH, USA.
W Henry BoomDivision of Infectious Diseases and HIV Medicine, Department of Medicine, Cleveland, OH, USA.
Clifford HardingDepartment of Pathology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Stephen M CarpenterDivision of Infectious Diseases and HIV Medicine, Department of Medicine, Cleveland, OH, USA.ORCID 0000-0001-9879-327X

Funding

IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) - SARS-CoV-2 RELATED RESEARCH75N93019C00070 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI URDAHL, KEVIN · 2019 to 2025
$86.6M
IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB)75N93019C00071 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI FORTUNE, SARAH · 2019 to 2025
$57.3M
Evaluating human T cells specific for Mycobacterium tuberculosis antigens that are processed and presented by infected macrophagesR01AI187662 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI Stephen Matthew Carpenter · 2025 to 2026
$1.6M
Determining Protective Features of Human Memory T-cells to Inform Mycobacterium tuberculosis Vaccine DevelopmentK08AI163407 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI Stephen Matthew Carpenter · 2022 to 2026
$967k
Overcoming restrained lung trafficking by memory CD4+ T cells to prevent active tuberculosis in people living with HIVR21AI167675 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI CARPENTER, STEPHEN MATTHEW, FREEMAN, MICHAEL L · 2022 to 2023
$443k
NIAID NIH HHS K08 AI163407NIAID NIH HHS R01 AI187662NIAID NIH HHS R21 AI167675NIH HHS 75N93019C00070NIH HHS 75N93019C00071
6 · The paper itself

Abstract

Control of

Indexed as

bystanderCD4decoyextracellular vesiclesIFNγinfected macrophagememoryMycobacterium tuberculosisrecognitionsoluble antigensTBT celltype VII secretion system

Identifiers

PMID42818070
PMCPMC13622055

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.