Evidence map›Paper›PMID 42818052›Full record

ArticlebioRxiv : the preprint server for biology2026

Gene therapy with doxycycline-controlled expression of human Kv1.1 reduces neuronal excitability and increases sociability of

Brody A Deming, Jingliang Zhang, Iuliia Vitko, Ronald P Gaykema, Manasi Halurkar, Zaiyang Zhang, Akila D Abeyaratna, Rineet Ranga, Purba Mandal, Kathryn Lund and 4 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Brody A DemingBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University.ORCID 0000-0002-1404-5694
Jingliang ZhangBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University.
Iuliia VitkoUniversity of Virginia School of Medicine, Charlottesville, VA 22903.
Ronald P GaykemaUniversity of Virginia School of Medicine, Charlottesville, VA 22903.
Manasi HalurkarBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University.
Zaiyang ZhangBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University.
Akila D AbeyaratnaBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University.
Rineet RangaBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University.
Purba MandalBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University.
Kathryn LundBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University.
Keeley FarmerBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University.
Deepti RamasamyBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University.
Edward Perez-ReyesUniversity of Virginia School of Medicine, Charlottesville, VA 22903.
Yang YangBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University.ORCID 0000-0001-6417-3654

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genetic loss-of-function (LoF) variants in

Indexed as

autism spectrum disordersociabilityvoltage-gated potassium channelvoltage-gated sodium channel

Identifiers

PMID42818052
PMCPMC13622227

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.