Evidence map›Paper›PMID 42818051›Full record

ArticlebioRxiv : the preprint server for biology2026

IFN-κ directs antiviral immunity in human skin.

Jafira M Johnson, Laurellee Payne, Pooja Parameswaran, Yongzhi Chen, Mrinal K Sarkar, Anthony M Coon, J Michelle Kahlenberg, Johann E Gudjonsson, Katherine A Fitzgerald, Mehdi Rashighi and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jafira M JohnsonDivision of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA.
Laurellee PayneDivision of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA.
Pooja ParameswaranDivision of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA.
Yongzhi ChenProgram in Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA.
Mrinal K SarkarDepartment of Dermatology, University of Michigan, Ann Arbor, MI.
Anthony M CoonDepartment of Dermatology, University of Michigan, Ann Arbor, MI.
J Michelle KahlenbergDepartment of Dermatology, University of Michigan, Ann Arbor, MI.
Johann E GudjonssonDepartment of Dermatology, University of Michigan, Ann Arbor, MI.
Katherine A FitzgeraldProgram in Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA.
Mehdi RashighiDepartment of Dermatology, University of Massachusetts Chan Medical School, Worcester, MA.
Megan H OrzalliDivision of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA.

Funding

University of Michigan Skin Biology and Diseases Resource-based CenterP30AR075043 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Johann Eli Gudjonsson · 2019 to 2026
$6.6M
Innate Immunity Training ProgramT32AI095213 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SILVERMAN, NEAL · 2011 to 2025
$2.5M
Regulation of the NLRP1 inflammasome by HSV-1R01AI182052 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Megan Horn Orzalli · 2025 to 2026
$1.3M
The role of constitutive interferon-kappa production in antiviral defense in human skinF31AI189083 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Jafira Marie Johnson · 2026 to 2026
$35k
NIAID NIH HHS F31 AI189083NIAID NIH HHS R01 AI182052NIAID NIH HHS T32 AI095213NIAMS NIH HHS P30 AR075043
6 · The paper itself

Abstract

Inducible expression of type I IFNs is a well-established host innate defense mechanism to limit virus infection. Yet, many viruses have evolved strategies to suppress the induction of these cytokines to enhance replication, spread, and transmission between hosts. Whether additional antiviral mechanisms protect against infection when inducible responses are compromised is not well understood. Here, we demonstrate that human keratinocytes preemptively protect the skin against virus infection through constitutive production of IFN-kappa (IFN-κ), a poorly studied type I IFN family member. We find that constitutive

Identifiers

PMID42818051
PMCPMC13622050

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.