Evidence map›Paper›PMID 42818042›Full record

ArticlebioRxiv : the preprint server for biology2026

Mapping and rewiring the

Aaron Renberg, Savannah Coppersmith, Owen Merritt, Yao-Chang Tsan, Esraa Ismail, Jennasea Licata, Maya Sheth, Revant Gupta, Anshul Kundaje, Sabrina Friedline and 11 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Aaron RenbergDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-8782-9342
Savannah CoppersmithDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0009-0002-5932-8628
Owen MerrittDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0009-0002-7743-8943
Yao-Chang TsanDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0003-0373-1290
Esraa IsmailDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Jennasea LicataDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0009-0007-7062-060X
Maya ShethDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-1466-8899
Revant GuptaDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-0881-5074
Anshul KundajeDepartment of Computer Science, Stanford University, Stanford, CA, USA.ORCID 0000-0003-3084-2287
Sabrina FriedlineDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Hayden C HelmsDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Elizabeth D HughesDepartment of Computer Science, Stanford University, Stanford, CA, USA.
Zachary T FreemanBasic Sciences and Engineering Initiative, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital, Stanford, CA, USA.
George PowellNational Heart and Lung Institute and MRC Laboratory of Medical Sciences, Imperial College, London, UK.
James S WareNational Heart and Lung Institute and MRC Laboratory of Medical Sciences, Imperial College, London, UK.
Joshua MeisnerDepartment of Pediatrics, Division of Pediatric Cardiology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0003-1049-8351
Eric M SmithDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Adelaide TovarDepartment of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0003-1699-7231
Jesse M EngreitzDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-5754-1719
Jacob KitzmanDepartment of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-6145-882X
Adam S HelmsDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-0234-6430

Funding

TRAINING IN MOLECULAR AND CELLULAR CARDIOLOGYT32HL007853 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI David J. Pinsky · 1996 to 2026
$11.6M
Advancing Child Health Through Cellular and Molecular BiologyK12HD028820 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Donna M. Martin · 2002 to 2026
$9.2M
Cellular and Molecular Biology at MichiganT32GM145470 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI John Chadwick Brenner · 2022 to 2026
$4.1M
Michigan Medical Scientist Training Program 2025-2030T32GM156550 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kathleen L. Collins · 2025 to 2026
$3.2M
Mapping, programming, and correcting gene regulatory sequences for Alagille SyndromeR01HL171609 · NHLBI · STANFORD UNIVERSITY · PI JESSE M ENGREITZ, Marlene Rabinovitch · 2024 to 2026
$2.3M
Cis regulatory variants of haploinsufficiency genes as cardiomyopathy modifiersR01HL171074 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ADAM S HELMS · 2024 to 2026
$2.1M
Expanding the Reach of Massively Parallel Variant Effect ScreensR35GM153286 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jacob Otto Kitzman · 2024 to 2026
$1.5M
An integrative genomics toolkit for rewriting regulatory DNA to reprogram gene expressionR01HL184893 · NHLBI · STANFORD UNIVERSITY · PI JESSE M ENGREITZ · 2026 to 2026
$770k
Mechanical and Metabolic Pathways Underlying MYBPC3 Hypertrophic CardiomyopathyK08HL179262 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Joshua K Meisner · 2025 to 2026
$335k
NHLBI NIH HHS K08 HL179262NHLBI NIH HHS R01 HL171074NHLBI NIH HHS R01 HL171609NHLBI NIH HHS R01 HL184893NHLBI NIH HHS T32 HL007853NICHD NIH HHS K12 HD028820NIGMS NIH HHS R35 GM153286NIGMS NIH HHS T32 GM145470NIGMS NIH HHS T32 GM156550Wellcome Trust
6 · The paper itself

Abstract

Autosomal dominant loss-of-function variants in the gene

Identifiers

PMID42818042
PMCPMC13622176

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.