Evidence map›Paper›PMID 42818026›Full record

ArticlebioRxiv : the preprint server for biology2026

Convergent evolutionary loss of chemosensory and blood-feeding pathways in non-blood-feeding mosquitoes.

Leah Houri-Zeevi, Philipp Brand, Irene Arnoldi, Alexandra E DeFoe, Jennifer R Balacco, Nadav Shai, Alex Makunin, Umberto Palatini, Takako Toma, Takao Okazawa and 8 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Leah Houri-ZeeviLaboratory of Neurogenetics and Behavior, The Rockefeller University, New York, NY 10065 United States of America.ORCID 0000-0003-2903-5082
Philipp BrandLaboratory of Neurophysiology and Behavior, The Rockefeller University, New York, NY 10065 United States of America.ORCID 0000-0003-4287-4753
Irene ArnoldiLaboratory of Entomology and Parasitology (EntoPar), Department of Biosciences, University of Milan, Milan 20133 Italy.ORCID 0000-0001-8018-4417
Alexandra E DeFoeLaboratory of Neurogenetics and Behavior, The Rockefeller University, New York, NY 10065 United States of America.ORCID 0009-0003-0344-327X
Jennifer R BalaccoVertebrate Genome Lab, The Rockefeller University, New York, NY 10065 United States of America.ORCID 0000-0001-7102-1632
Nadav ShaiLaboratory of Neurogenetics and Behavior, The Rockefeller University, New York, NY 10065 United States of America.ORCID 0000-0002-2812-3884
Alex MakuninTree of Life, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA United Kingdom.ORCID 0000-0002-9555-5097
Umberto PalatiniLaboratory of Neurogenetics and Behavior, The Rockefeller University, New York, NY 10065 United States of America.ORCID 0000-0002-2435-2655
Takako TomaUniversity of the Ryukyus Museum (Fujukan), 903-0213, Japan.
Takao OkazawaDepartment of Parasitology, Graduate School of Medical Science, Kanazawa University, Kanazawa 920-8640 Japan.
Christopher M StoneIllinois Natural History Survey, Prairie Research Institute, University of Illinois Urbana-Champaign, Champaign, IL 61820 United States of America.ORCID 0000-0001-9535-2583
Anita SchillerHarris County PCT4 Mosquito Biological Control Initiative, Houston, TX 77379 United States of America.ORCID 0009-0002-0769-5899
Olivier FedrigoVertebrate Genome Lab, The Rockefeller University, New York, NY 10065 United States of America.ORCID 0000-0002-6450-7551
Erich D JarvisHoward Hughes Medical Institute, New York, NY 10065 United States of America.ORCID 0000-0001-8931-5049
Mara K N LawniczakTree of Life, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA United Kingdom.ORCID 0000-0002-3006-2080
Ichiro MiyagiUniversity of the Ryukyus Museum (Fujukan), 903-0213, Japan.
Paolo GabrieliLaboratory of Entomology and Parasitology (EntoPar), Department of Biosciences, University of Milan, Milan 20133 Italy.ORCID 0000-0002-4996-2468
Leslie B VosshallLaboratory of Neurogenetics and Behavior, The Rockefeller University, New York, NY 10065 United States of America.ORCID 0000-0002-6060-8099

Funding

Functional mechanisms of environmental control over social behaviorK99GM151471 · NIGMS · ROCKEFELLER UNIVERSITY · PI BRAND, PHILIPP · 2023 to 2024
$250k
NIGMS NIH HHS K99 GM151471Wellcome Trust
6 · The paper itself

Abstract

Complex traits that span multiple tissues and systems often integrate large numbers of genes across development, physiology, and behavior, making it challenging to identify their essential components. Blood feeding in mosquitoes is one such trait. It is ancestral to the mosquito family, maintained in most species for ~200 million years, and was independently lost in three lineages. These convergent losses offer a natural experiment to discover the genetic, physiological, and neural features required for blood feeding. We assembled high-quality, chromosome-level genomes for seven mosquito species, along with whole-brain tomographic reconstructions. Our study spanned the three known non-blood-feeding lineages (

Identifiers

PMID42818026
PMCPMC13622201

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.