Evidence map›Paper›PMID 42818012›Full record

ArticlebioRxiv : the preprint server for biology2026

Structural basis of stepwise G protein activation by the viral chemokine receptor US28.

Kevin M Jude, Carl-Mikael Suomivuori, Deepa Waghray, Shoji Maeda, Yoshinori Fujiyoshi, Asuka Inoue, K Christopher Garcia, Naotaka Tsutsumi

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kevin M JudeHoward Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-3675-5136
Carl-Mikael SuomivuoriDepartment of Pharmacology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-2445-8791
Deepa WaghrayDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Shoji MaedaDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-7762-9793
Yoshinori FujiyoshiCellular and Structural Physiology Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Bunkyo, Tokyo, Japan.ORCID 0000-0002-8070-1493
Asuka InoueGraduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.ORCID 0000-0003-0805-4049
K Christopher GarciaHoward Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-9273-0278
Naotaka TsutsumiCellular and Structural Physiology Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Bunkyo, Tokyo, Japan.ORCID 0000-0002-3617-7145

Funding

Viral GPCR recognition of chemokines and engineered ligandsR01AI125320 · NIAID · STANFORD UNIVERSITY · PI GARCIA, KENAN CHRISTOPHER · 2016 to 2020
$2.0M
NIAID NIH HHS R01 AI125320
6 · The paper itself

Abstract

G protein-coupled receptors (GPCRs) govern diverse cellular responses and are crucial drug targets. However, the sequence of structural events from G protein recognition to GDP release has remained elusive. Here, we leveraged the viral chemokine GPCR US28 to capture multiple activation states of the US28-G

Identifiers

PMID42818012
PMCPMC13621993

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.