Evidence map›Paper›PMID 42818002›Full record

ArticlebioRxiv : the preprint server for biology2026

Auditory brainstem response amplitude predicts age-related forward masking temporal-processing deficits in normal-hearing listeners.

Chengjie G Huang, Milena Costantino, Roksana Soleimanpour, Taylor Beinke, Samira Anderson, Matthew J Goupell

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chengjie G HuangDepartment of Hearing and Speech Sciences, University of Maryland, College Park, Maryland, USA, 20742.
Milena CostantinoCollege of Computer, Mathematical, and Natural Sciences, University of Maryland, College Park, Maryland, USA, 20742.
Roksana SoleimanpourCollege of Computer, Mathematical, and Natural Sciences, University of Maryland, College Park, Maryland, USA, 20742.
Taylor BeinkeDepartment of Hearing and Speech Sciences, University of Maryland, College Park, Maryland, USA, 20742.
Samira AndersonDepartment of Hearing and Speech Sciences, University of Maryland, College Park, Maryland, USA, 20742.
Matthew J GoupellDepartment of Hearing and Speech Sciences, University of Maryland, College Park, Maryland, USA, 20742.

Funding

Peripheral and central contributions to auditory temporal processing deficits and speech understanding in older cochlear implanteesR01DC020316 · NIDCD · UNIV OF MARYLAND, COLLEGE PARK · PI Matthew J. Goupell · 2022 to 2026
$2.7M
NIDCD NIH HHS R01 DC020316
6 · The paper itself

Abstract

Aging has profound effects on sensory systems, such that older adults can report problems in hearing despite having normal audiometric thresholds. While it is known that older listeners have poorer temporal processing than younger listeners, there is limited understanding of how these deficits interact with effects of sound level, in particular when they are above conversational level (e.g., > 65 dB SPL). Here we wanted to investigate the link between temporal processing and sound level as a function of age in normal-hearing listeners. Using a forward-masking paradigm, auditory brainstem responses (ABRs) and behavioral detection thresholds were measured at different masker levels. It was found that with increasing age and masker sound level, older listeners' Wave V amplitudes decreased and directly correlated with behavioral detection thresholds of the probe stimulus in the forward-masking paradigm. These results elucidate the fundamental effects of aging on temporal processing and its interactions with sound level in the central auditory system. The results of this study have clinical implications for the concept of "normal hearing" in the aging population and how older listeners may struggle in different listening environments that are not captured by simple audiometry. Further delineating the important effects of aging will pave the way for earlier clinical diagnosis of hearing disorders and personalized treatments for different forms of age-related hearing loss.

Identifiers

PMID42818002
PMCPMC13622137

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.