Evidence map›Paper›PMID 42817986›Full record

ArticlebioRxiv : the preprint server for biology2026

Exogenous L6 myotube mitochondrial transplantation attenuates hypertrophy and elicits a unique proteomic signature in phenylephrine-treated H9C2 cardiomyocytes.

Nicholas J Kontos, George J Kontos, Dustyn T Lewis, Samuel C Norton, Bradley A Ruple, Andreas N Kavazis, Darren T Beck, Melissa D Boersma, Christopher B Mobley, Danielle J McCullough and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nicholas J KontosSchool of Kinesiology, Auburn University, Auburn, AL, USA.
George J KontosSchool of Kinesiology, Auburn University, Auburn, AL, USA.
Dustyn T LewisSchool of Kinesiology, Auburn University, Auburn, AL, USA.
Samuel C NortonSchool of Kinesiology, Auburn University, Auburn, AL, USA.
Bradley A RupleDepartment of Radiology, University of Washington Medicine, Seattle, WA, USA.
Andreas N KavazisSchool of Kinesiology, Auburn University, Auburn, AL, USA.
Darren T BeckSchool of Kinesiology, Auburn University, Auburn, AL, USA.
Melissa D BoersmaDepartment of Chemistry and Biochemistry, Auburn University, Auburn, AL, USA.
Christopher B MobleySchool of Kinesiology, Auburn University, Auburn, AL, USA.
Danielle J McCulloughEdward Via College of Osteopathic Medicine-Auburn Campus, Auburn, AL, USA.
Ahmed IsmaeelDepartment of Physiology, College of Veterinary Medicine, Auburn University, Auburn, AL, USA.
Michael D RobertsSchool of Kinesiology, Auburn University, Auburn, AL, USA.

Funding

Biological Mechanisms of Healthy Aging Training GrantT32AG066574 · NIA · UNIVERSITY OF WASHINGTON · PI David J. Marcinek, Jessica E Young · 2020 to 2026
$5.3M
NIA NIH HHS T32 AG066574
6 · The paper itself

Abstract

Mitochondrial transplantation has recently emerged as an alternative treatment for cardiovascular disease (CVD), aimed at increasing mitochondrial number and improving mitochondrial function. Though mitochondrial dysfunction is a key factor in the development of right ventricular hypertrophy/failure, the effects of mitochondrial transplantation on disease mitigation have been largely unexplored. Therefore, this

Indexed as

bioenergeticsH9C2 cardiomyocyteshypertrophyMitochondrial transplantationphenylephrineproteomics

Identifiers

PMID42817986
PMCPMC13622122

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.