Evidence map›Paper›PMID 42817951›Full record

ArticlebioRxiv : the preprint server for biology2026

A Chemigenetic Fluorescence Lifetime Biosensor for Dopamine Sensing.

Anh-Thu Nguyen, Hieu Tran, Limin Chen, Abby Criswell, Susanna Bradbury, Yui Zhu, Yujie He, Sohyun Kim, Yuan-I Chen, Trung Duc Nguyen and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Anh-Thu NguyenDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.
Hieu TranDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.
Limin ChenDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.
Abby CriswellDepartment of Psychiatry & Behavioral Science, The University of Texas at Austin Dell Medical School, Austin, TX, USA.
Susanna BradburyDepartment of Psychiatry & Behavioral Science, The University of Texas at Austin Dell Medical School, Austin, TX, USA.
Yui ZhuDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.
Yujie HeDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.
Sohyun KimDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.
Yuan-I ChenDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.
Trung Duc NguyenDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.
Soonwoo HongDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.
Yu-An KuoDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.
Saeed SeifiDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.
Wei-Ru ChenDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.
Stephanie K SeidlitsDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.
Lief E FennoDepartment of Psychiatry & Behavioral Science, The University of Texas at Austin Dell Medical School, Austin, TX, USA.
Hsin-Chih YehDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Measuring the precise dynamics of specific neuromodulators in neurons is key to understanding how information is transmitted and processed in the brain. Despite the growing use of intensity-based neural activity sensors such as dLight in recent years, it remains challenging to monitor the dynamics of multiple neurochemicals simultaneously in live neurons. Unlike intensiometric sensors that are susceptible to artifacts caused by fluctuations in excitation power and rapid photobleaching, fluorescence lifetime-based sensors are less affected by these factors and can provide more stable measurements. Here we introduce dHaloLife

Identifiers

PMID42817951
PMCPMC13622053

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.