ArticlebioRxiv : the preprint server for biology2026
Surviving phage attack primes bacterial immunity to defeat counterdefenses.
Reid T Oshiro, Alyssa A Pratt, Drew T Dunham, Lindsey A Doyle, Clare Gill, Ani Chouldjian, Kerilyn M Higashi, Julieta Peralta Acosta, Sydney F McGuire, Sam Nouwens and 2 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
12 authors.
Reid T OshiroDepartment of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA USA.ORCID 0000-0002-8419-1048 Alyssa A PrattDepartment of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA USA.
Drew T DunhamDepartment of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA USA.
Lindsey A DoyleDivision of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, WA USA.
Clare GillDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA USA.
Ani ChouldjianDepartment of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA USA.
Kerilyn M HigashiDepartment of Biology, Seattle University, Seattle, WA USA.
Julieta Peralta AcostaDepartment of Biology, Seattle University, Seattle, WA USA.
Sydney F McGuireDepartment of Biology, Seattle University, Seattle, WA USA.
Sam NouwensDepartment of Biology, Seattle University, Seattle, WA USA.
Kimberley D SeedDepartment of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA USA.ORCID 0000-0002-0139-1600 Funding
User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PAUL David ADAMS, Gregory L Hura · 2017 to 2026
$28.6MGENOMICST32HG000047 · NHGRI · UNIVERSITY OF CALIFORNIA BERKELEY · PI RASMUS NIELSEN, Daniel Soleyman Rokhsar · 2000 to 2026
$13.5MGenetic Dissection of Cells and Organisms Training ProgramT32GM132022 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Nicole King, NOAH K WHITEMAN · 2019 to 2026
$5.2MPhage resistance and mobile genetic elements in Vibrio choleraeR01AI127652 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI SEED, KIMBERLEY DIANE · 2016 to 2025
$4.6MPilatus 6mS10OD021832 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI ADAMS, PAUL DAVID · 2016 to 2016
$980kNHGRI NIH HHS T32 HG000047NIAID NIH HHS R01 AI127652NIGMS NIH HHS P30 GM124169NIGMS NIH HHS T32 GM132022NIH HHS S10 OD021832
6 · The paper itselfAbstract
Transcriptional repressors with ligand-responsive WYL domains control diverse bacterial defense systems, yet the natural cues driving derepression and the physiological rationale for dynamic regulation in native host-phage contexts remain unknown. Here, we show that restricted phage infection, where defense clears a primary attack, serves as a natural cue for WYL-mediated derepression in
Identifiers
PMID42817947
PMCPMC13622015
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