ArticleCancer reports (Hoboken, N.J.)2026
Regulation of ER Stress-Associated Gene Expression by Lifeguard in Human Breast Cancer Cells.
Article in Cancer reports (Hoboken, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
backgroundDespite significant advances in breast cancer therapy, resistance to apoptosis remains a major obstacle to successful treatment. Lifeguard (LFG), an antiapoptotic membrane protein, has been implicated in breast cancer progression; however, its role in endoplasmic reticulum (ER) stress-associated molecular responses and apoptosis-related gene regulation remains incompletely understood.
aimsThis study aimed to investigate molecular changes associated with LFG-targeted siRNA treatment and reduced LFG mRNA expression in human breast cancer cells. METHODS AND
resultsThe triple-negative breast cancer cell line MDA-MB-231 and the non-tumorigenic mammary epithelial cell line MCF10A were transfected with LFG-specific siRNA. LFG mRNA expression was analyzed by quantitative RT-PCR. Furthermore, ER stress- and apoptosis-related gene expression was examined using an RT
conclusionsThese findings demonstrate that LFG-targeted siRNA treatment and reduced LFG mRNA expression are associated with changes in intracellular calcium-related responses and ER stress- and apoptosis-associated gene expression, particularly in MDA-MB-231 cells. Further studies are required to determine the underlying mechanisms and establish the functional role of LFG in these cellular responses.
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