ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2026
Regulation of cellular proteostasis via mitochondrial protein import.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Mitochondria are the powerhouse of the cell, playing vital roles in energy production and metabolism. Most mitochondrial proteins are encoded in the nuclear DNA and must be synthesized in the cytosol before being transported into the appropriate mitochondrial compartments. Mitochondrial protein import is not only essential for mitochondrial biogenesis but also a crucial regulatory step in mitochondrial proteostasis surveillance and stress response. Additionally, defects in mitochondrial protein import lead to mislocalization of precursor proteins to the cytosol, disrupting cytosolic proteostasis and contributing to various human diseases. This review summarizes recent findings demonstrating that mitochondrial protein import is a key regulator of cellular proteostasis. This article is part of the Theo Murphy meeting issue 'ProteostaSys: a systems view of proteostasis'.
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