Evidence map›Paper›PMID 42817574›Full record

ArticleChemistry & biodiversity2026

Bombyx mori-Hosted Cordyceps militaris Polysaccharides: Structural Characterization and Antibacterial Activity of Native and Sulfated Derivatives.

Jingchun Yang, Jiani Cheng, Gaoyang Li, Wenpu Shi, Yaqi Liu, Tingyu Luo, Lixue Zheng

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Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Jingchun YangSchool of Biology and Food Engineering, Suzhou University of Technology, Changshu, Jiangsu, China.
Jiani ChengSchool of Biology and Food Engineering, Suzhou University of Technology, Changshu, Jiangsu, China.
Gaoyang LiSchool of Biology and Food Engineering, Suzhou University of Technology, Changshu, Jiangsu, China.
Wenpu ShiSchool of Biology and Food Engineering, Suzhou University of Technology, Changshu, Jiangsu, China.
Yaqi LiuSchool of Biology and Food Engineering, Suzhou University of Technology, Changshu, Jiangsu, China.
Tingyu LuoSuzhou Xinfudi Agricultural Products Market Development Co., Ltd., Changshu, Jiangsu, China.
Lixue ZhengSchool of Biology and Food Engineering, Suzhou University of Technology, Changshu, Jiangsu, China.ORCID https://orcid.org/0000-0002-5332-8697

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polysaccharides from Bombyx mori-hosted Cordyceps militaris are abundant but exhibit limited bioactivity, necessitating exploration of sulfated derivatives. In this study, crude polysaccharides (Bm-CMP) were extracted and further sulfated to obtain four derivatives (Bm-sCMP-1∼4). Physicochemical and structural analyses indicated that sulfation significantly modified the characteristics of Bm-CMP, notably reducing the molecular weight (Mw) and particle size while enhancing the negative surface charge and altering the monosaccharide profile. All sulfated derivatives exerted enhanced inhibitory effects against Escherichia coli and Bacillus subtilis, which were closely dependent on the degree of substitution (DS), sulfate content, and negative charge density. Notably, Bm-sCMP-2, with a moderate DS, displayed the optimal antibacterial efficacy. Collectively, this work demonstrates that sulfation is a feasible strategy to valorize polysaccharides from B. mori-hosted C. militaris, transforming them into promising candidates for novel antibacterial agents, although their in vivo efficacy and safety require further validation.

Indexed as

Anti-Bacterial AgentsBombyxCordycepsPolysaccharidesSulfatesAnimalsBacillus subtilisEscherichia coliMicrobial Sensitivity TestsMolecular WeightStructure-Activity RelationshipAnti-Bacterial AgentsPolysaccharidesSulfatesantibacterial activityBombyx mori‐hosted Cordyceps militarispolysaccharidesstructural characterizationsulfated modification

Identifiers

PMID42817574
PMCPMC13628141

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.