ArticleSensors (Basel, Switzerland)2026
Longitudinal Changes in Systemic Total Oxidant Status Following High-Intensity Focused Ultrasound for Facial Rejuvenation: A Prospective 6-Month Controlled Pilot Study.
Foteini Biskanaki, Vasilis Papadopoulos, Ioanna A Anastasiou, Nikolaos Tentolouris, Ilias Velissariou, Sofia Georgia Pantazi, George Skouras, Dimitrios Chaniotis, Fragiskos Chaniotis, Effie G Papageorgiou and 3 more
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In one paragraphArticle in Sensors (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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13 authors.
Foteini BiskanakiFirst Department of Pathology, School of Medicine, The National and Kapodistrian University of Athens, 11527 Athens, Greece.ORCID 0000-0003-4061-6531 Vasilis PapadopoulosFirst Department of Pathology, School of Medicine, The National and Kapodistrian University of Athens, 11527 Athens, Greece.ORCID 0000-0003-4325-4599 Ioanna A AnastasiouDiabetes Center, First Department of Propaedeutic Internal Medicine, School of Medicine, The National and Kapodistrian University of Athens, 11527 Athens, Greece.ORCID 0000-0002-7560-0575 Nikolaos TentolourisDiabetes Center, First Department of Propaedeutic Internal Medicine, School of Medicine, The National and Kapodistrian University of Athens, 11527 Athens, Greece.ORCID 0000-0003-0615-2534 Ilias VelissariouFirst Department of Pathology, School of Medicine, The National and Kapodistrian University of Athens, 11527 Athens, Greece.
Sofia Georgia PantaziFirst Department of Pathology, School of Medicine, The National and Kapodistrian University of Athens, 11527 Athens, Greece.
George SkourasDepartment of Plastic Surgery, SkourasMed Clinic, 10673 Athens, Greece.
Dimitrios ChaniotisDepartment of Biomedical Sciences, School of Health and Care Sciences, University of West Attica, 12243 Athens, Greece.ORCID 0000-0003-2313-1305 Fragiskos ChaniotisDepartment of Biomedical Sciences, School of Health and Care Sciences, University of West Attica, 12243 Athens, Greece.
Effie G PapageorgiouDepartment of Biomedical Sciences, School of Health and Care Sciences, University of West Attica, 12243 Athens, Greece.
Athanasia VarvaresouDepartment of Biomedical Sciences, School of Health and Care Sciences, University of West Attica, 12243 Athens, Greece.ORCID 0000-0002-6932-8763 Evaggelia ProtopapaDepartment of Biomedical Sciences, School of Health and Care Sciences, University of West Attica, 12243 Athens, Greece.
Andreas C LazarisFirst Department of Pathology, School of Medicine, The National and Kapodistrian University of Athens, 11527 Athens, Greece.ORCID 0000-0002-8118-7780 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
High-intensity focused ultrasound (HIFU) is widely used for non-invasive facial and neck rejuvenation; however, its longer-term systemic biochemical effects remain insufficiently characterized. This prospective controlled pilot study investigated longitudinal changes in systemic oxidative status at baseline and 3 and 6 months following a single HIFU treatment. Thirty healthy adults were enrolled, including 25 participants who underwent facial and neck HIFU and 5 untreated participants serving as a comparison group. Serum total oxidant status (TOS) was quantified using an enzyme-linked immunosorbent assay (ELISA)-based method, and longitudinal changes were assessed using mixed-effects modeling. Baseline TOS did not differ significantly between groups (19.54 ± 1.49 vs. 19.78 ± 1.81 μmol/L;
Indexed as
FaceOxidantsRejuvenationAdultFemaleHumansLongitudinal StudiesMaleMiddle AgedOxidative StressPilot ProjectsProspective StudiesOxidantsELISAfacial rejuvenationhigh-intensity focused ultrasound (HIFU)longitudinal assessmentoxidative stresssystemic biomarker monitoringtotal oxidant status
Identifiers
PMID42817560
PMCPMC13611138
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