ArticleSensors (Basel, Switzerland)2026
Optofluidic Sensing and Sorting of Chiral Drugs Based on Core-Shell Composite Microspheres.
Article in Sensors (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Current all-optical chiral sorting approaches are ineffective for nanoscale drug molecules with weak chirality, as their faint optical response cannot maintain the chiral sorting mechanism. To overcome this physical limitation, the theoretical study proposes a core-shell composite chiral sensing microsphere, in which a drug crystal core is encapsulated by a nematic liquid crystal shell, acting as a chirality-amplifying carrier for optofluidic detection. Using a sodium ibuprofen nanocrystal as a representative weakly chiral drug, the optimal core-shell sensing structure was determined to consist of a nematic liquid crystal E7 shell with a radius of 19 μm and a sodium ibuprofen crystal core with a radius of 9.5 μm. This optimized configuration amplifies the molecular chirality parameter from 10
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